TY - JOUR
T1 - Role of estrogen receptor-α on food demand elasticity
AU - Minervini, Vanessa
AU - Rowland, Neil E.
AU - Robertson, Kimberly L.
AU - Foster, Thomas C.
N1 - Publisher Copyright:
© Society for the Experimental Analysis of Behavior.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Estrogens have been shown to have an inhibitory effect on food intake under free-feeding conditions, yet the effects of estrogens on food-maintained operant responding have been studied to a much lesser extent and, thus, are not well understood. Therefore, the purpose of the present experiment was to use a behavioral economics paradigm to assess differences in demand elasticity between mice with knockout of the estrogen receptor subtype α, knockout of subtype β, and their wild type controls. The mice responded in a closed economy, and the price of food was increased by increasing the fixed-ratio response requirement every four sessions. Overall, we found that mice with the knockout of receptor subtype α had the most elastic demand functions. Therefore, under these conditions, estrogens increased food seeking via activation of the receptor subtype α. The results were inconsistent with those reported by previous studies that employed free-feeding conditions.
AB - Estrogens have been shown to have an inhibitory effect on food intake under free-feeding conditions, yet the effects of estrogens on food-maintained operant responding have been studied to a much lesser extent and, thus, are not well understood. Therefore, the purpose of the present experiment was to use a behavioral economics paradigm to assess differences in demand elasticity between mice with knockout of the estrogen receptor subtype α, knockout of subtype β, and their wild type controls. The mice responded in a closed economy, and the price of food was increased by increasing the fixed-ratio response requirement every four sessions. Overall, we found that mice with the knockout of receptor subtype α had the most elastic demand functions. Therefore, under these conditions, estrogens increased food seeking via activation of the receptor subtype α. The results were inconsistent with those reported by previous studies that employed free-feeding conditions.
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U2 - 10.1002/jeab.149
DO - 10.1002/jeab.149
M3 - Article
C2 - 25869426
AN - SCOPUS:84929134317
VL - 103
SP - 553
EP - 561
JO - Journal of the Experimental Analysis of Behavior
JF - Journal of the Experimental Analysis of Behavior
SN - 0022-5002
IS - 3
ER -