Abstract
Hsp70 is a highly conserved protein that refolds misfolded proteins and has numerous housekeeping functions which regulate apoptosis and other cell activities. Hsp70 consists of a nucleotide binding domain which binds ATP and a substrate binding domain that binds misfolded proteins. The substrate binding domain contains a peptide binding pocket which is covered by a helical lid. In humans, there are three major cytosolic Hsp70 isotypes, Hsp70-8, Hsp70-1 and Hsp70-2. Leukemic and numerous other cancer cells have a greater amount of Hsp70-1 and -2, which help the cancer cells inhibit apoptosis in response to stress. This review summarizes the structure and role of Hsp70 proteins in cancer survival.
| Original language | English |
|---|---|
| Pages (from-to) | 616-624 |
| Number of pages | 9 |
| Journal | Protein and Peptide Letters |
| Volume | 19 |
| Issue number | 6 |
| State | Published - Jun 2012 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Structural Biology
Cite this
Role of hsp70 in cancer growth and survival. / Hatfield, Marcus P D; Lovas, Sándor.
In: Protein and Peptide Letters, Vol. 19, No. 6, 06.2012, p. 616-624.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Role of hsp70 in cancer growth and survival
AU - Hatfield, Marcus P D
AU - Lovas, Sándor
PY - 2012/6
Y1 - 2012/6
N2 - Hsp70 is a highly conserved protein that refolds misfolded proteins and has numerous housekeeping functions which regulate apoptosis and other cell activities. Hsp70 consists of a nucleotide binding domain which binds ATP and a substrate binding domain that binds misfolded proteins. The substrate binding domain contains a peptide binding pocket which is covered by a helical lid. In humans, there are three major cytosolic Hsp70 isotypes, Hsp70-8, Hsp70-1 and Hsp70-2. Leukemic and numerous other cancer cells have a greater amount of Hsp70-1 and -2, which help the cancer cells inhibit apoptosis in response to stress. This review summarizes the structure and role of Hsp70 proteins in cancer survival.
AB - Hsp70 is a highly conserved protein that refolds misfolded proteins and has numerous housekeeping functions which regulate apoptosis and other cell activities. Hsp70 consists of a nucleotide binding domain which binds ATP and a substrate binding domain that binds misfolded proteins. The substrate binding domain contains a peptide binding pocket which is covered by a helical lid. In humans, there are three major cytosolic Hsp70 isotypes, Hsp70-8, Hsp70-1 and Hsp70-2. Leukemic and numerous other cancer cells have a greater amount of Hsp70-1 and -2, which help the cancer cells inhibit apoptosis in response to stress. This review summarizes the structure and role of Hsp70 proteins in cancer survival.
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UR - http://www.scopus.com/inward/citedby.url?scp=84861942110&partnerID=8YFLogxK
M3 - Review article
VL - 19
SP - 616
EP - 624
JO - Protein and Peptide Letters
JF - Protein and Peptide Letters
SN - 0929-8665
IS - 6
ER -