Role of intracellular calcium in peroxide-induced potentiation of norepinephrine release from bovine isolated irides

Catherine A. Opere, Sunny E. Ohia

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1. BAPTA AM (10 μM), thapsigargin (10 μM), ruthenium red (30 μM) and oligomycin (30 μM) inhibited field-stimulated [3H]NE release from bovine isolated irides by 54%, 30%, 30% and 26%, respectively. 2. Both BAPTA AM and thapsigargin had no significant effect (P>0.05) on H2O2-induced potentiation of evoked [3H]NE release. 3. Ruthenium red prevented (but oligomycin enhanced) H2O2-induced enhancement of evoked [3H]NE release. 4. We conclude that, although intracellular calcium participates in field-stimulation evoked [3H]NE release from bovine isolated irides, only the mitochondrial pool of calcium may be involved in peroxide-induced enhancement of sympathetic neurotransmission. Copyright (C) 1998 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)793-798
Number of pages6
JournalGeneral Pharmacology
Issue number5
Publication statusPublished - Nov 1998


All Science Journal Classification (ASJC) codes

  • Pharmacology

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