TY - JOUR
T1 - Role of intracellular calcium in peroxide-induced potentiation of norepinephrine release from bovine isolated irides
AU - Opere, Catherine A.
AU - Ohia, Sunny E.
PY - 1998/11
Y1 - 1998/11
N2 - 1. BAPTA AM (10 μM), thapsigargin (10 μM), ruthenium red (30 μM) and oligomycin (30 μM) inhibited field-stimulated [3H]NE release from bovine isolated irides by 54%, 30%, 30% and 26%, respectively. 2. Both BAPTA AM and thapsigargin had no significant effect (P>0.05) on H2O2-induced potentiation of evoked [3H]NE release. 3. Ruthenium red prevented (but oligomycin enhanced) H2O2-induced enhancement of evoked [3H]NE release. 4. We conclude that, although intracellular calcium participates in field-stimulation evoked [3H]NE release from bovine isolated irides, only the mitochondrial pool of calcium may be involved in peroxide-induced enhancement of sympathetic neurotransmission. Copyright (C) 1998 Elsevier Science Inc.
AB - 1. BAPTA AM (10 μM), thapsigargin (10 μM), ruthenium red (30 μM) and oligomycin (30 μM) inhibited field-stimulated [3H]NE release from bovine isolated irides by 54%, 30%, 30% and 26%, respectively. 2. Both BAPTA AM and thapsigargin had no significant effect (P>0.05) on H2O2-induced potentiation of evoked [3H]NE release. 3. Ruthenium red prevented (but oligomycin enhanced) H2O2-induced enhancement of evoked [3H]NE release. 4. We conclude that, although intracellular calcium participates in field-stimulation evoked [3H]NE release from bovine isolated irides, only the mitochondrial pool of calcium may be involved in peroxide-induced enhancement of sympathetic neurotransmission. Copyright (C) 1998 Elsevier Science Inc.
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U2 - 10.1016/S0306-3623(98)00090-1
DO - 10.1016/S0306-3623(98)00090-1
M3 - Article
C2 - 9809480
AN - SCOPUS:0032213225
VL - 31
SP - 793
EP - 798
JO - Vascular Pharmacology
JF - Vascular Pharmacology
SN - 1537-1891
IS - 5
ER -