Abstract
1. BAPTA AM (10 μM), thapsigargin (10 μM), ruthenium red (30 μM) and oligomycin (30 μM) inhibited field-stimulated [3H]NE release from bovine isolated irides by 54%, 30%, 30% and 26%, respectively. 2. Both BAPTA AM and thapsigargin had no significant effect (P>0.05) on H2O2-induced potentiation of evoked [3H]NE release. 3. Ruthenium red prevented (but oligomycin enhanced) H2O2-induced enhancement of evoked [3H]NE release. 4. We conclude that, although intracellular calcium participates in field-stimulation evoked [3H]NE release from bovine isolated irides, only the mitochondrial pool of calcium may be involved in peroxide-induced enhancement of sympathetic neurotransmission. Copyright (C) 1998 Elsevier Science Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 793-798 |
| Number of pages | 6 |
| Journal | General Pharmacology |
| Volume | 31 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 1998 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
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Role of intracellular calcium in peroxide-induced potentiation of norepinephrine release from bovine isolated irides. / Opere, Catherine A.; Ohia, Sunny E.
In: General Pharmacology, Vol. 31, No. 5, 11.1998, p. 793-798.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of intracellular calcium in peroxide-induced potentiation of norepinephrine release from bovine isolated irides
AU - Opere, Catherine A.
AU - Ohia, Sunny E.
PY - 1998/11
Y1 - 1998/11
N2 - 1. BAPTA AM (10 μM), thapsigargin (10 μM), ruthenium red (30 μM) and oligomycin (30 μM) inhibited field-stimulated [3H]NE release from bovine isolated irides by 54%, 30%, 30% and 26%, respectively. 2. Both BAPTA AM and thapsigargin had no significant effect (P>0.05) on H2O2-induced potentiation of evoked [3H]NE release. 3. Ruthenium red prevented (but oligomycin enhanced) H2O2-induced enhancement of evoked [3H]NE release. 4. We conclude that, although intracellular calcium participates in field-stimulation evoked [3H]NE release from bovine isolated irides, only the mitochondrial pool of calcium may be involved in peroxide-induced enhancement of sympathetic neurotransmission. Copyright (C) 1998 Elsevier Science Inc.
AB - 1. BAPTA AM (10 μM), thapsigargin (10 μM), ruthenium red (30 μM) and oligomycin (30 μM) inhibited field-stimulated [3H]NE release from bovine isolated irides by 54%, 30%, 30% and 26%, respectively. 2. Both BAPTA AM and thapsigargin had no significant effect (P>0.05) on H2O2-induced potentiation of evoked [3H]NE release. 3. Ruthenium red prevented (but oligomycin enhanced) H2O2-induced enhancement of evoked [3H]NE release. 4. We conclude that, although intracellular calcium participates in field-stimulation evoked [3H]NE release from bovine isolated irides, only the mitochondrial pool of calcium may be involved in peroxide-induced enhancement of sympathetic neurotransmission. Copyright (C) 1998 Elsevier Science Inc.
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UR - http://www.scopus.com/inward/citedby.url?scp=0032213225&partnerID=8YFLogxK
U2 - 10.1016/S0306-3623(98)00090-1
DO - 10.1016/S0306-3623(98)00090-1
M3 - Article
C2 - 9809480
AN - SCOPUS:0032213225
VL - 31
SP - 793
EP - 798
JO - Vascular Pharmacology
JF - Vascular Pharmacology
SN - 1537-1891
IS - 5
ER -