Role of risk stratification and genetics in sudden cardiac death

Vikrant Rai, Devendra K. Agrawal

    Research output: Contribution to journalReview articlepeer-review

    6 Scopus citations

    Abstract

    Sudden cardiac death (SCD) is a major public health issue due to its increasing incidence in the general population and the difficulty in identifying high-risk individuals. Nearly 300 000–350 000 patients in the United States and 4–5 million patients in the world die annually from SCD. Coronary artery disease and advanced heart failure are the main etiology for SCD. Ischemia of any cause precipitates lethal arrhythmias, and ventricular tachycardia and ventricular fibrillation are the most common lethal arrhythmias precipitating SCD. Pulseless electrical activity, bradyarrhythmia, and electromechanical dissociation also result in SCD. Most SCDs occur outside of the hospital setting, so it is difficult to estimate the public burden, which results in overestimating the incidence of SCD. The insufficiency and limited predictive value of various indicators and criteria for SCD result in the increasing incidence. As a result, there is a need to develop better risk stratification criteria and find modifiable variables to decrease the incidence. Primary and secondary prevention and treatment of SCD need further research. This critical review is focused on the etiology, risk factors, prognostic factors, and importance of risk stratification of SCD.

    Original languageEnglish (US)
    Pages (from-to)225-238
    Number of pages14
    JournalCanadian Journal of Physiology and Pharmacology
    Volume95
    Issue number3
    DOIs
    StatePublished - 2016

    All Science Journal Classification (ASJC) codes

    • Medicine(all)
    • Physiology
    • Pharmacology
    • Physiology (medical)

    Fingerprint

    Dive into the research topics of 'Role of risk stratification and genetics in sudden cardiac death'. Together they form a unique fingerprint.

    Cite this