Runs of homozygosity identify a recessive locus 12q21.31 for human adult height

Tie Lin Yang, Yan Guo, Li Shu Zhang, Qing Tian, Han Yan, Christopher J. Papasian, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Background: Runs of homozygosity (ROHs) have recently been proposed to have potential recessive significance for complex traits. Human adult height is a classic complex trait with heritability estimated up to 90%, and recessive loci that contribute to adult height variation have been identified. Methods: Using the Affymetrix 500K array set, we performed a genome-wide ROHs analysis to identify genetic loci for adult height in a discovery sample including 998 unrelated Caucasian subjects from the midwest United States. For the significant ROHs identified, we replicated these findings in a family-based sample of 8385 Caucasian subjects from the Framingham Heart Study (FHS). Results: Our results revealed one ROH, located in 12q21.31, that had a strong association with adult height variation both in the discovery (P = 6.69 × 10-6) and replication samples (P = 5.40 × 10-5). We further validated the presence of this ROH using the HapMap sample. Conclusion: Our findings open a new avenue for identifying loci with recessive contributions to adult height variation. Further molecular and functional studies are needed to explore and clarify the potential mechanism.

Original languageEnglish (US)
Pages (from-to)3777-3782
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Issue number8
StatePublished - Aug 2010

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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