Safety and diagnostic accuracy of adenosine-thallium imaging in the elderly

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Abstract

To assess the safety of intravenous adenosine myocardial perfusion imaging in the elderly, we compared the outcome of younger and older patients from a cohort of 774 consecutive patients. Adenosine was administered as a 0.14-mg/kg/min constant infusion for 6 min. There were 596 (77%) patients aged ≤ 70 years (group 1) and 178 (23%) patients aged > 70 years (group 2). The incidence of noncardiac side effects (such as flushing, headache, etc.) and cardiac side effects (such as chest pain, ST segment depression, and hypotension) was not different between the two groups. There was a statistically nonsignificant increase in 2nd- and 3rd-degree atrioventricular block and in the discontinuation rate of adenosine in older patients. This was not associated with a clinically relevant adverse outcome. Other than age, there were no other variables predictive of differences in adverse outcome. The use of adenosine for myocardial perfusion imaging is as safe in younger patients as it is in older patients. There is a higher incidence of atrioventricular block and adenosine discontinuation in the elderly, but it is not associated with a clinically relevant adverse outcome.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalAmerican Journal of Noninvasive Cardiology
Volume8
Issue number1
StatePublished - 1994

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Thallium
Adenosine
Safety
Myocardial Perfusion Imaging
Atrioventricular Block
Incidence
Chest Pain
Hypotension
Headache

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Safety and diagnostic accuracy of adenosine-thallium imaging in the elderly",
abstract = "To assess the safety of intravenous adenosine myocardial perfusion imaging in the elderly, we compared the outcome of younger and older patients from a cohort of 774 consecutive patients. Adenosine was administered as a 0.14-mg/kg/min constant infusion for 6 min. There were 596 (77{\%}) patients aged ≤ 70 years (group 1) and 178 (23{\%}) patients aged > 70 years (group 2). The incidence of noncardiac side effects (such as flushing, headache, etc.) and cardiac side effects (such as chest pain, ST segment depression, and hypotension) was not different between the two groups. There was a statistically nonsignificant increase in 2nd- and 3rd-degree atrioventricular block and in the discontinuation rate of adenosine in older patients. This was not associated with a clinically relevant adverse outcome. Other than age, there were no other variables predictive of differences in adverse outcome. The use of adenosine for myocardial perfusion imaging is as safe in younger patients as it is in older patients. There is a higher incidence of atrioventricular block and adenosine discontinuation in the elderly, but it is not associated with a clinically relevant adverse outcome.",
author = "Mohiuddin, {Syed M.} and Esterbrooks, {Dennis J.} and Hilleman, {Daniel E.} and Gupta, {N. C.} and Hunter, {Claire B.}",
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AU - Mohiuddin, Syed M.

AU - Esterbrooks, Dennis J.

AU - Hilleman, Daniel E.

AU - Gupta, N. C.

AU - Hunter, Claire B.

PY - 1994

Y1 - 1994

N2 - To assess the safety of intravenous adenosine myocardial perfusion imaging in the elderly, we compared the outcome of younger and older patients from a cohort of 774 consecutive patients. Adenosine was administered as a 0.14-mg/kg/min constant infusion for 6 min. There were 596 (77%) patients aged ≤ 70 years (group 1) and 178 (23%) patients aged > 70 years (group 2). The incidence of noncardiac side effects (such as flushing, headache, etc.) and cardiac side effects (such as chest pain, ST segment depression, and hypotension) was not different between the two groups. There was a statistically nonsignificant increase in 2nd- and 3rd-degree atrioventricular block and in the discontinuation rate of adenosine in older patients. This was not associated with a clinically relevant adverse outcome. Other than age, there were no other variables predictive of differences in adverse outcome. The use of adenosine for myocardial perfusion imaging is as safe in younger patients as it is in older patients. There is a higher incidence of atrioventricular block and adenosine discontinuation in the elderly, but it is not associated with a clinically relevant adverse outcome.

AB - To assess the safety of intravenous adenosine myocardial perfusion imaging in the elderly, we compared the outcome of younger and older patients from a cohort of 774 consecutive patients. Adenosine was administered as a 0.14-mg/kg/min constant infusion for 6 min. There were 596 (77%) patients aged ≤ 70 years (group 1) and 178 (23%) patients aged > 70 years (group 2). The incidence of noncardiac side effects (such as flushing, headache, etc.) and cardiac side effects (such as chest pain, ST segment depression, and hypotension) was not different between the two groups. There was a statistically nonsignificant increase in 2nd- and 3rd-degree atrioventricular block and in the discontinuation rate of adenosine in older patients. This was not associated with a clinically relevant adverse outcome. Other than age, there were no other variables predictive of differences in adverse outcome. The use of adenosine for myocardial perfusion imaging is as safe in younger patients as it is in older patients. There is a higher incidence of atrioventricular block and adenosine discontinuation in the elderly, but it is not associated with a clinically relevant adverse outcome.

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