Salivary lysozyme and prevalent hypertension

M. Qvarnstrom, S. Janket, J. A. Jones, P. Nuutinen, A. E. Baird, Martha E. Nunn, T. E. Van Dyke, J. H. Meurman

Research output: Contribution to journalArticle

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Abstract

Although the etiology of essential hypertension is not clearly understood, endothelial dysfunction from chronic infection and/or impaired glucose metabolism may be involved. We hypothesized that salivary lysozyme, a marker for oral infection and hyperglycemia, might display a significant relationship with hypertension, an early stage of cardiovascular disease. Logistic regression analyses of the Kuopio Oral Health and Heart Study demonstrated that persons with higher lysozyme levels were more likely to have hypertension, after adjustment for age, gender, smoking, BMI, diabetes, the ratio of total cholesterol to HDL cholesterol, and C-reactive protein. The exposure to increasing quartiles of lysozyme was associated with adjusted Odds Ratios for the outcome, hypertension, 1.00 (referent), 1.25, 1.42, and 2.56 (linear trend p <0.003). When we restricted the sample to the individuals without heart disease (N = 250), we observed a non-significant trend for increasing odds. Our hypothesis - "high salivary lysozyme levels are associated with the odds of hypertension" - was confirmed.

Original languageEnglish
Pages (from-to)480-484
Number of pages5
JournalJournal of Dental Research
Volume87
Issue number5
DOIs
StatePublished - May 2008
Externally publishedYes

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Muramidase
Hypertension
Oral Health
Infection
Hyperglycemia
C-Reactive Protein
HDL Cholesterol
Heart Diseases
Cardiovascular Diseases
Logistic Models
Smoking
Odds Ratio
Cholesterol
Regression Analysis
Glucose

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Qvarnstrom, M., Janket, S., Jones, J. A., Nuutinen, P., Baird, A. E., Nunn, M. E., ... Meurman, J. H. (2008). Salivary lysozyme and prevalent hypertension. Journal of Dental Research, 87(5), 480-484. https://doi.org/10.1177/154405910808700507

Salivary lysozyme and prevalent hypertension. / Qvarnstrom, M.; Janket, S.; Jones, J. A.; Nuutinen, P.; Baird, A. E.; Nunn, Martha E.; Van Dyke, T. E.; Meurman, J. H.

In: Journal of Dental Research, Vol. 87, No. 5, 05.2008, p. 480-484.

Research output: Contribution to journalArticle

Qvarnstrom, M, Janket, S, Jones, JA, Nuutinen, P, Baird, AE, Nunn, ME, Van Dyke, TE & Meurman, JH 2008, 'Salivary lysozyme and prevalent hypertension', Journal of Dental Research, vol. 87, no. 5, pp. 480-484. https://doi.org/10.1177/154405910808700507
Qvarnstrom M, Janket S, Jones JA, Nuutinen P, Baird AE, Nunn ME et al. Salivary lysozyme and prevalent hypertension. Journal of Dental Research. 2008 May;87(5):480-484. https://doi.org/10.1177/154405910808700507
Qvarnstrom, M. ; Janket, S. ; Jones, J. A. ; Nuutinen, P. ; Baird, A. E. ; Nunn, Martha E. ; Van Dyke, T. E. ; Meurman, J. H. / Salivary lysozyme and prevalent hypertension. In: Journal of Dental Research. 2008 ; Vol. 87, No. 5. pp. 480-484.
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