Abstract
Although the etiology of essential hypertension is not clearly understood, endothelial dysfunction from chronic infection and/or impaired glucose metabolism may be involved. We hypothesized that salivary lysozyme, a marker for oral infection and hyperglycemia, might display a significant relationship with hypertension, an early stage of cardiovascular disease. Logistic regression analyses of the Kuopio Oral Health and Heart Study demonstrated that persons with higher lysozyme levels were more likely to have hypertension, after adjustment for age, gender, smoking, BMI, diabetes, the ratio of total cholesterol to HDL cholesterol, and C-reactive protein. The exposure to increasing quartiles of lysozyme was associated with adjusted Odds Ratios for the outcome, hypertension, 1.00 (referent), 1.25, 1.42, and 2.56 (linear trend p <0.003). When we restricted the sample to the individuals without heart disease (N = 250), we observed a non-significant trend for increasing odds. Our hypothesis - "high salivary lysozyme levels are associated with the odds of hypertension" - was confirmed.
| Original language | English |
|---|---|
| Pages (from-to) | 480-484 |
| Number of pages | 5 |
| Journal | Journal of Dental Research |
| Volume | 87 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2008 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Dentistry(all)
Cite this
Salivary lysozyme and prevalent hypertension. / Qvarnstrom, M.; Janket, S.; Jones, J. A.; Nuutinen, P.; Baird, A. E.; Nunn, Martha E.; Van Dyke, T. E.; Meurman, J. H.
In: Journal of Dental Research, Vol. 87, No. 5, 05.2008, p. 480-484.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Salivary lysozyme and prevalent hypertension
AU - Qvarnstrom, M.
AU - Janket, S.
AU - Jones, J. A.
AU - Nuutinen, P.
AU - Baird, A. E.
AU - Nunn, Martha E.
AU - Van Dyke, T. E.
AU - Meurman, J. H.
PY - 2008/5
Y1 - 2008/5
N2 - Although the etiology of essential hypertension is not clearly understood, endothelial dysfunction from chronic infection and/or impaired glucose metabolism may be involved. We hypothesized that salivary lysozyme, a marker for oral infection and hyperglycemia, might display a significant relationship with hypertension, an early stage of cardiovascular disease. Logistic regression analyses of the Kuopio Oral Health and Heart Study demonstrated that persons with higher lysozyme levels were more likely to have hypertension, after adjustment for age, gender, smoking, BMI, diabetes, the ratio of total cholesterol to HDL cholesterol, and C-reactive protein. The exposure to increasing quartiles of lysozyme was associated with adjusted Odds Ratios for the outcome, hypertension, 1.00 (referent), 1.25, 1.42, and 2.56 (linear trend p <0.003). When we restricted the sample to the individuals without heart disease (N = 250), we observed a non-significant trend for increasing odds. Our hypothesis - "high salivary lysozyme levels are associated with the odds of hypertension" - was confirmed.
AB - Although the etiology of essential hypertension is not clearly understood, endothelial dysfunction from chronic infection and/or impaired glucose metabolism may be involved. We hypothesized that salivary lysozyme, a marker for oral infection and hyperglycemia, might display a significant relationship with hypertension, an early stage of cardiovascular disease. Logistic regression analyses of the Kuopio Oral Health and Heart Study demonstrated that persons with higher lysozyme levels were more likely to have hypertension, after adjustment for age, gender, smoking, BMI, diabetes, the ratio of total cholesterol to HDL cholesterol, and C-reactive protein. The exposure to increasing quartiles of lysozyme was associated with adjusted Odds Ratios for the outcome, hypertension, 1.00 (referent), 1.25, 1.42, and 2.56 (linear trend p <0.003). When we restricted the sample to the individuals without heart disease (N = 250), we observed a non-significant trend for increasing odds. Our hypothesis - "high salivary lysozyme levels are associated with the odds of hypertension" - was confirmed.
UR - http://www.scopus.com/inward/record.url?scp=43749119366&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43749119366&partnerID=8YFLogxK
U2 - 10.1177/154405910808700507
DO - 10.1177/154405910808700507
M3 - Article
C2 - 18434581
AN - SCOPUS:43749119366
VL - 87
SP - 480
EP - 484
JO - Journal of Dental Research
JF - Journal of Dental Research
SN - 0022-0345
IS - 5
ER -