SBLA syndrome revisited

H. T. Lynch, B. Radford, J. F. Lynch

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

We have provided an in-depth, longitudinal, clinical/genetic/pathologic investigation of a family consonant with the sarcoma, breast cancer and brain tumors, lung and laryngeal cancer, leukemia, lymphoma, and adrenalcortical carcinoma syndrome. The pattern of cancer expression involves all three germinal layers with transmission through multiple generations. Segregation of these cancers occur in a manner consonant with an autosomal dominant mode of genetic transmission. It is hoped that recognition of the significance of this tumor pattern within families will provide an impetus for cancer surveillance, control, and laboratory research in the quest for clues to biomarkers which correlate with its cancer-prone genotype.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalOncology
Volume47
Issue number1
DOIs
StatePublished - Jan 1 1990

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Lynch, H. T., Radford, B., & Lynch, J. F. (1990). SBLA syndrome revisited. Oncology, 47(1), 75-79. https://doi.org/10.1159/000226789