SBLA syndrome revisited

Henry T. Lynch, B. Radford, J. F. Lynch

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We have provided an in-depth, longitudinal, clinical/genetic/pathologic investigation of a family consonant with the sarcoma, breast cancer and brain tumors, lung and laryngeal cancer, leukemia, lymphoma, and adrenalcortical carcinoma syndrome. The pattern of cancer expression involves all three germinal layers with transmission through multiple generations. Segregation of these cancers occur in a manner consonant with an autosomal dominant mode of genetic transmission. It is hoped that recognition of the significance of this tumor pattern within families will provide an impetus for cancer surveillance, control, and laboratory research in the quest for clues to biomarkers which correlate with its cancer-prone genotype.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalOncology
Volume47
Issue number1
StatePublished - 1990

Fingerprint

Brain Neoplasms
Neoplasms
Breast Neoplasms
Laryngeal Neoplasms
Sarcoma
Lymphoma
Lung Neoplasms
Leukemia
Biomarkers
Genotype
Carcinoma
Research

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Lynch, H. T., Radford, B., & Lynch, J. F. (1990). SBLA syndrome revisited. Oncology, 47(1), 75-79.

SBLA syndrome revisited. / Lynch, Henry T.; Radford, B.; Lynch, J. F.

In: Oncology, Vol. 47, No. 1, 1990, p. 75-79.

Research output: Contribution to journalArticle

Lynch, HT, Radford, B & Lynch, JF 1990, 'SBLA syndrome revisited', Oncology, vol. 47, no. 1, pp. 75-79.
Lynch HT, Radford B, Lynch JF. SBLA syndrome revisited. Oncology. 1990;47(1):75-79.
Lynch, Henry T. ; Radford, B. ; Lynch, J. F. / SBLA syndrome revisited. In: Oncology. 1990 ; Vol. 47, No. 1. pp. 75-79.
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