Screening Adherence in BRCA1/2 Families Is Associated with Primary Physicians' Behavior

Susan T. Tinley, Julia Houfek, Patrice Watson, Lari Wenzel, Mary Beth Clark, Susan Coughlin, Henry T. Lynch

Research output: Contribution to journalArticle

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Abstract

This study provides an assessment of long-term breast and ovarian cancer screening behaviors and the variables associated with adherence with screening among women with or at 50% for having a BRCA1/2 mutation. Participants in the study included 112 women (33 mutation carriers and 79 at 50% risk). Data was collected through a mailed questionnaire, which included items to assess screening behaviors in the last 2 years, risk perception, cancer specific distress, adherence determinants, specific barriers, and cancer history. Statistical analysis included descriptive statistics and non-parametric tests to describe bivariate associations and regression analysis. Adherence rates were 72% for annual mammography, 21% for semi-annual clinical breast exam (CBE), 29% for monthly breast self-exam (BSE), and 19% for annual transvaginal ultrasound (US). Only one participant was adherent with semi-annual CA125. Variables that had a significant association (P <0.05) with at least one screening modality included: a lack of time, marital status, education, cancer history, provider concern, perceived screening utility, confidence in ability to overcome barriers, cancer specific distress, and risk perception. Primary physician behavior, either in terms of screening recommendations or screening performance in the case of CBE, had significant independent association with adherence to mammography, CBE, and US screening recommendations. The results of this study highlight the essential role that primary physicians play in supporting their very high-risk patients' adherence.

Original languageEnglish
Pages (from-to)5-11
Number of pages7
JournalAmerican Journal of Medical Genetics
Volume125 A
Issue number1
StatePublished - Feb 15 2004

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Breast
Physicians
Mammography
Neoplasms
Physician's Role
Mutation
Aptitude
Marital Status
Patient Compliance
Nonparametric Statistics
Early Detection of Cancer
Ovarian Neoplasms
Regression Analysis
Breast Neoplasms
Education

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)

Cite this

Tinley, S. T., Houfek, J., Watson, P., Wenzel, L., Clark, M. B., Coughlin, S., & Lynch, H. T. (2004). Screening Adherence in BRCA1/2 Families Is Associated with Primary Physicians' Behavior. American Journal of Medical Genetics, 125 A(1), 5-11.

Screening Adherence in BRCA1/2 Families Is Associated with Primary Physicians' Behavior. / Tinley, Susan T.; Houfek, Julia; Watson, Patrice; Wenzel, Lari; Clark, Mary Beth; Coughlin, Susan; Lynch, Henry T.

In: American Journal of Medical Genetics, Vol. 125 A, No. 1, 15.02.2004, p. 5-11.

Research output: Contribution to journalArticle

Tinley, ST, Houfek, J, Watson, P, Wenzel, L, Clark, MB, Coughlin, S & Lynch, HT 2004, 'Screening Adherence in BRCA1/2 Families Is Associated with Primary Physicians' Behavior', American Journal of Medical Genetics, vol. 125 A, no. 1, pp. 5-11.
Tinley ST, Houfek J, Watson P, Wenzel L, Clark MB, Coughlin S et al. Screening Adherence in BRCA1/2 Families Is Associated with Primary Physicians' Behavior. American Journal of Medical Genetics. 2004 Feb 15;125 A(1):5-11.
Tinley, Susan T. ; Houfek, Julia ; Watson, Patrice ; Wenzel, Lari ; Clark, Mary Beth ; Coughlin, Susan ; Lynch, Henry T. / Screening Adherence in BRCA1/2 Families Is Associated with Primary Physicians' Behavior. In: American Journal of Medical Genetics. 2004 ; Vol. 125 A, No. 1. pp. 5-11.
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