Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers

a case-control study

Steven A. Narod, Jan Lubinski, Parviz Ghadirian, Henry T. Lynch, Pal Moller, William D. Foulkes, Barry Rosen, Charmaine Kim-Sing, Claudine Isaacs, Susan Domcheck, Ping Sun

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Background: Screening mammography is associated with a small dose of radiation to the breast, and women with increased genetic risk might be particularly sensitive to the DNA-damaging effects of ionising radiation. We aimed to assess whether exposure to ionising radiation through mammography screening was associated with risk of breast cancer in BRCA1 or BRCA2 mutation carriers. Methods: We identified 1600 cases of breast cancer and 1600 controls without breast cancer who were matched for BRCA mutation, date of birth (within 1 year), and country of residence from an international registry of BRCA1 and BRCA2 mutation carriers. We used a questionnaire to inquire about whether participants had ever had screening mammography, and, if so, the age at which they first had the procedure. Results: We found no association between ever having screening mammography and risk of breast cancer (odds ratio [OR] 1·03 [95% CI 0·85-1·25], adjusted for parity, oral-contraceptive use, ethnic origin, and bilateral oophorectomy). The association was much the same for BRCA1 mutation carriers and BRCA2 mutation carriers (1·04 [0·84-1·29] vs 1·06 [0·67-1·66], respectively, adjusted for parity, oral-contraceptive use, ethnic origin, and bilateral oophorectomy). Interpretation: These findings do not lend support to the idea that exposure to ionising radiation through routine screening mammography contributes substantially to the burden of breast cancer in BRCA1 and BRCA2 mutation carriers. Prospective studies are needed to confirm the results of this initial report, and, where possible, these studies should assess a more appropriate endpoint of total exposure.

Original languageEnglish
Pages (from-to)402-406
Number of pages5
JournalThe Lancet Oncology
Volume7
Issue number5
DOIs
StatePublished - May 2006

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Mammography
Case-Control Studies
Breast Neoplasms
Mutation
Ionizing Radiation
Ovariectomy
Oral Contraceptives
Parity
Registries
Breast
Odds Ratio
Parturition
Prospective Studies
Radiation
DNA

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers : a case-control study. / Narod, Steven A.; Lubinski, Jan; Ghadirian, Parviz; Lynch, Henry T.; Moller, Pal; Foulkes, William D.; Rosen, Barry; Kim-Sing, Charmaine; Isaacs, Claudine; Domcheck, Susan; Sun, Ping.

In: The Lancet Oncology, Vol. 7, No. 5, 05.2006, p. 402-406.

Research output: Contribution to journalArticle

Narod, SA, Lubinski, J, Ghadirian, P, Lynch, HT, Moller, P, Foulkes, WD, Rosen, B, Kim-Sing, C, Isaacs, C, Domcheck, S & Sun, P 2006, 'Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study', The Lancet Oncology, vol. 7, no. 5, pp. 402-406. https://doi.org/10.1016/S1470-2045(06)70624-6
Narod, Steven A. ; Lubinski, Jan ; Ghadirian, Parviz ; Lynch, Henry T. ; Moller, Pal ; Foulkes, William D. ; Rosen, Barry ; Kim-Sing, Charmaine ; Isaacs, Claudine ; Domcheck, Susan ; Sun, Ping. / Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers : a case-control study. In: The Lancet Oncology. 2006 ; Vol. 7, No. 5. pp. 402-406.
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AU - Ghadirian, Parviz

AU - Lynch, Henry T.

AU - Moller, Pal

AU - Foulkes, William D.

AU - Rosen, Barry

AU - Kim-Sing, Charmaine

AU - Isaacs, Claudine

AU - Domcheck, Susan

AU - Sun, Ping

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N2 - Background: Screening mammography is associated with a small dose of radiation to the breast, and women with increased genetic risk might be particularly sensitive to the DNA-damaging effects of ionising radiation. We aimed to assess whether exposure to ionising radiation through mammography screening was associated with risk of breast cancer in BRCA1 or BRCA2 mutation carriers. Methods: We identified 1600 cases of breast cancer and 1600 controls without breast cancer who were matched for BRCA mutation, date of birth (within 1 year), and country of residence from an international registry of BRCA1 and BRCA2 mutation carriers. We used a questionnaire to inquire about whether participants had ever had screening mammography, and, if so, the age at which they first had the procedure. Results: We found no association between ever having screening mammography and risk of breast cancer (odds ratio [OR] 1·03 [95% CI 0·85-1·25], adjusted for parity, oral-contraceptive use, ethnic origin, and bilateral oophorectomy). The association was much the same for BRCA1 mutation carriers and BRCA2 mutation carriers (1·04 [0·84-1·29] vs 1·06 [0·67-1·66], respectively, adjusted for parity, oral-contraceptive use, ethnic origin, and bilateral oophorectomy). Interpretation: These findings do not lend support to the idea that exposure to ionising radiation through routine screening mammography contributes substantially to the burden of breast cancer in BRCA1 and BRCA2 mutation carriers. Prospective studies are needed to confirm the results of this initial report, and, where possible, these studies should assess a more appropriate endpoint of total exposure.

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