Searching for obesity genes

Progress and prospects

Yong Jun Liu, Peng Xiao, Dong Hai Xiong, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Obesity is a condition of excess body fat that causes or exacerbates several major public health problems. Remarkable progress has been made in the molecular elucidation of monogenic forms of obesity both in rodents and in humans. The most common form of obesity, however, is considered to be a polygenic disorder arising from the interaction of multiple genetic and environmental factors. Identification and characterization of susceptibility genes underlying obesity will contribute to a greater understanding of the pathogenesis of obesity and ultimately will assist in the development of better strategies for prevention and therapeutic intervention. In this article, we discuss the current status and future perspectives for the genetic dissection of obesity, with a focus on the most striking or representative findings.

Original languageEnglish
Pages (from-to)345-362
Number of pages18
JournalDrugs of Today
Volume41
Issue number5
DOIs
StatePublished - May 2005

Fingerprint

Obesity
Genes
Adipose Tissue
Dissection
Rodentia
Public Health
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology (medical)
  • Pharmacology

Cite this

Searching for obesity genes : Progress and prospects. / Liu, Yong Jun; Xiao, Peng; Xiong, Dong Hai; Recker, Robert R.; Deng, Hong Wen.

In: Drugs of Today, Vol. 41, No. 5, 05.2005, p. 345-362.

Research output: Contribution to journalReview article

Liu, Yong Jun ; Xiao, Peng ; Xiong, Dong Hai ; Recker, Robert R. ; Deng, Hong Wen. / Searching for obesity genes : Progress and prospects. In: Drugs of Today. 2005 ; Vol. 41, No. 5. pp. 345-362.
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