Sebaceous skin lesions as clues to hereditary non-polyposis colorectal cancer

Henry T. Lynch, Ramon M. Fusaro, Patrick M. Lynch

Research output: Contribution to journalComment/debatepeer-review

13 Scopus citations


Cutaneous lesions consonant with Muir-Torre syndrome strongly suggest hereditary non-polyposis colorectal cancer (HNPCC). Ponti et al. discuss the importance of combining molecular genetic features of the sebaceous neoplasms, including microsatellite instability and immunohistochemistry, with family history, to determine the likelihood of HNPCC. Proof of diagnosis is identification of one of the mismatch repair germline mutations.

Original languageEnglish (US)
Pages (from-to)2158-2159
Number of pages2
JournalJournal of Investigative Dermatology
Issue number10
StatePublished - Oct 30 2006

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology


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