Sebaceous skin lesions as clues to hereditary non-polyposis colorectal cancer

Henry T. Lynch, Ramon M. Fusaro, Patrick M. Lynch

Research output: Contribution to journalComment/debate

13 Scopus citations

Abstract

Cutaneous lesions consonant with Muir-Torre syndrome strongly suggest hereditary non-polyposis colorectal cancer (HNPCC). Ponti et al. discuss the importance of combining molecular genetic features of the sebaceous neoplasms, including microsatellite instability and immunohistochemistry, with family history, to determine the likelihood of HNPCC. Proof of diagnosis is identification of one of the mismatch repair germline mutations.

Original languageEnglish (US)
Pages (from-to)2158-2159
Number of pages2
JournalJournal of Investigative Dermatology
Volume126
Issue number10
DOIs
StatePublished - Oct 30 2006

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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