Sebaceous skin lesions as clues to hereditary non-polyposis colorectal cancer

Henry T. Lynch, Ramon M. Fusaro, Patrick M. Lynch

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Cutaneous lesions consonant with Muir-Torre syndrome strongly suggest hereditary non-polyposis colorectal cancer (HNPCC). Ponti et al. discuss the importance of combining molecular genetic features of the sebaceous neoplasms, including microsatellite instability and immunohistochemistry, with family history, to determine the likelihood of HNPCC. Proof of diagnosis is identification of one of the mismatch repair germline mutations.

Original languageEnglish
Pages (from-to)2158-2159
Number of pages2
JournalJournal of Investigative Dermatology
Volume126
Issue number10
DOIs
StatePublished - Oct 30 2006

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Microsatellite Repeats
Colorectal Neoplasms
Skin
Muir-Torre Syndrome
Repair
Microsatellite Instability
DNA Mismatch Repair
Germ-Line Mutation
Molecular Biology
Immunohistochemistry
Neoplasms

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Sebaceous skin lesions as clues to hereditary non-polyposis colorectal cancer. / Lynch, Henry T.; Fusaro, Ramon M.; Lynch, Patrick M.

In: Journal of Investigative Dermatology, Vol. 126, No. 10, 30.10.2006, p. 2158-2159.

Research output: Contribution to journalReview article

Lynch, Henry T. ; Fusaro, Ramon M. ; Lynch, Patrick M. / Sebaceous skin lesions as clues to hereditary non-polyposis colorectal cancer. In: Journal of Investigative Dermatology. 2006 ; Vol. 126, No. 10. pp. 2158-2159.
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