Segregation analysis of bronchial response to methacholine inhalation challenge in families with and without asthma

Robert G. Townley, Againdra Bewtra, Alexander F. Wilson, Russell J. Hopp, Robert C. Elston, Nicki Nair, Gavin D. Watt

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

A segregation analysis was performed on the bronchial response to a standardized methacholine inhalation challenge obtained from members of 83 families that were part of a Natural History of Asthma study population. Each bronchial response was expressed as the area under the best fitting parabolic dose-response curve. Standard methods of statistical analysis demonstrated that age, sex, and recent respiratory infection had a significant effect on the bronchial response to methacholine inhalation. Segregation analysis indicated that, although a familial component exists in the transmission of bronchial response to methacholine, the bimodal distribution of the bronchial response is not due to segregation at a single autosomal locus.

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
JournalThe Journal of Allergy and Clinical Immunology
Volume77
Issue number1 PART 1
DOIs
StatePublished - Jan 1986

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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