Abstract
A segregation analysis was performed on the bronchial response to a standardized methacholine inhalation challenge obtained from members of 83 families that were part of a Natural History of Asthma study population. Each bronchial response was expressed as the area under the best fitting parabolic dose-response curve. Standard methods of statistical analysis demonstrated that age, sex, and recent respiratory infection had a significant effect on the bronchial response to methacholine inhalation. Segregation analysis indicated that, although a familial component exists in the transmission of bronchial response to methacholine, the bimodal distribution of the bronchial response is not due to segregation at a single autosomal locus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 101-107 |
| Number of pages | 7 |
| Journal | The Journal of Allergy and Clinical Immunology |
| Volume | 77 |
| Issue number | 1 PART 1 |
| DOIs | |
| State | Published - Jan 1986 |
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
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Townley, R. G., Bewtra, A., Wilson, A. F., Hopp, R. J., Elston, R. C., Nair, N., & Watt, G. D. (1986). Segregation analysis of bronchial response to methacholine inhalation challenge in families with and without asthma. The Journal of Allergy and Clinical Immunology, 77(1 PART 1), 101-107. https://doi.org/10.1016/0091-6749(86)90330-1