Abstract
A segregation analysis was performed on the bronchial response to a standardized methacholine inhalation challenge obtained from members of 83 families that were part of a Natural History of Asthma study population. Each bronchial response was expressed as the area under the best fitting parabolic dose-response curve. Standard methods of statistical analysis demonstrated that age, sex, and recent respiratory infection had a significant effect on the bronchial response to methacholine inhalation. Segregation analysis indicated that, although a familial component exists in the transmission of bronchial response to methacholine, the bimodal distribution of the bronchial response is not due to segregation at a single autosomal locus.
| Original language | English |
|---|---|
| Pages (from-to) | 101-107 |
| Number of pages | 7 |
| Journal | Journal of Allergy and Clinical Immunology |
| Volume | 77 |
| Issue number | 1 PART 1 |
| DOIs | |
| State | Published - 1986 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Immunology
- Immunology and Allergy
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Segregation analysis of bronchial response to methacholine inhalation challenge in families with and without asthma. / Townley, Robert G.; Bewtra, Againdra K.; Wilson, Alexander F.; Hopp, Russell J.; Elston, Robert C.; Nair, Nicki; Watt, Gavin D.
In: Journal of Allergy and Clinical Immunology, Vol. 77, No. 1 PART 1, 1986, p. 101-107.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Segregation analysis of bronchial response to methacholine inhalation challenge in families with and without asthma
AU - Townley, Robert G.
AU - Bewtra, Againdra K.
AU - Wilson, Alexander F.
AU - Hopp, Russell J.
AU - Elston, Robert C.
AU - Nair, Nicki
AU - Watt, Gavin D.
PY - 1986
Y1 - 1986
N2 - A segregation analysis was performed on the bronchial response to a standardized methacholine inhalation challenge obtained from members of 83 families that were part of a Natural History of Asthma study population. Each bronchial response was expressed as the area under the best fitting parabolic dose-response curve. Standard methods of statistical analysis demonstrated that age, sex, and recent respiratory infection had a significant effect on the bronchial response to methacholine inhalation. Segregation analysis indicated that, although a familial component exists in the transmission of bronchial response to methacholine, the bimodal distribution of the bronchial response is not due to segregation at a single autosomal locus.
AB - A segregation analysis was performed on the bronchial response to a standardized methacholine inhalation challenge obtained from members of 83 families that were part of a Natural History of Asthma study population. Each bronchial response was expressed as the area under the best fitting parabolic dose-response curve. Standard methods of statistical analysis demonstrated that age, sex, and recent respiratory infection had a significant effect on the bronchial response to methacholine inhalation. Segregation analysis indicated that, although a familial component exists in the transmission of bronchial response to methacholine, the bimodal distribution of the bronchial response is not due to segregation at a single autosomal locus.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022640967&partnerID=8YFLogxK
U2 - 10.1016/0091-6749(86)90330-1
DO - 10.1016/0091-6749(86)90330-1
M3 - Article
VL - 77
SP - 101
EP - 107
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 1 PART 1
ER -