TY - JOUR
T1 - Selected conditions associated with an increased incidence of incisional hernia
T2 - A review of molecular biology
AU - Reilly, Matthew J.
AU - Larsen, Nicholas K.
AU - Agrawal, Swati
AU - Thankam, Finosh G.
AU - Agrawal, Devendra K.
AU - Fitzgibbons, Robert J.
N1 - Funding Information:
All authors have read the journal's authorship agreement and policy on disclosure of potential conflicts of interest. The authors declared no conflict of interest. Funding for the study was provided by the Department of Surgery, Creighton University.
Funding Information:
All authors have read the journal’s authorship agreement and policy on disclosure of potential conflicts of interest. The authors declared no conflict of interest. Funding for the study was provided by the Department of Surgery, Creighton University .
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/5
Y1 - 2021/5
N2 - Background: Incisional hernias (IH) following a laparotomy, on average, occur in 10–20% of patients, however, little is known about its molecular basis. Thus, a better understanding of the molecular mechanisms could lead to the identification of key target(s) to intervene pre-and post-operatively. Methods: We examined the current literature describing the molecular mechanisms of IH and overlap these factors with smoking, abdominal aortic aneurysm, obesity, diabetes mellitus, and diverticulitis. Results: The expression levels of collagen I and III, matrix metalloproteinases, and tissue inhibitors of metalloproteases are abnormal in the extracellular matrix (ECM) of IH patients and ECM disorganization has an overlap with these comorbid conditions. Conclusion: Understanding the pathophysiology of IH development and associated risk factors will allow physicians to identify patients that may be at increased risk for IH and to possibly act preemptively to decrease the incidence of IH.
AB - Background: Incisional hernias (IH) following a laparotomy, on average, occur in 10–20% of patients, however, little is known about its molecular basis. Thus, a better understanding of the molecular mechanisms could lead to the identification of key target(s) to intervene pre-and post-operatively. Methods: We examined the current literature describing the molecular mechanisms of IH and overlap these factors with smoking, abdominal aortic aneurysm, obesity, diabetes mellitus, and diverticulitis. Results: The expression levels of collagen I and III, matrix metalloproteinases, and tissue inhibitors of metalloproteases are abnormal in the extracellular matrix (ECM) of IH patients and ECM disorganization has an overlap with these comorbid conditions. Conclusion: Understanding the pathophysiology of IH development and associated risk factors will allow physicians to identify patients that may be at increased risk for IH and to possibly act preemptively to decrease the incidence of IH.
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U2 - 10.1016/j.amjsurg.2020.09.004
DO - 10.1016/j.amjsurg.2020.09.004
M3 - Review article
C2 - 32977928
AN - SCOPUS:85091498047
VL - 221
SP - 942
EP - 949
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 5
ER -