Self-administration of drugs of abuse

Steven I. Dworkin; Dustin J. Stairs

Self-administration of drugs of abuse

Steven I. Dworkin, Dustin J. Stairs

Department of Psychological Science

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

It has been over 40 years since the technical aspects of automatic intravenous drug delivery to rodents were described. 1 The development of self-administration methodology provided a tremendous technological advance for investigating drug abuse and resulted in clear demonstrations that the behavioral actions of psychoactive substances could be investigated using the same methods used to evaluate the reinforcing effects of nondrug reinforcers. The intravenous route of administration has several methodological advantages over other routes. The drug is discretely presented through an intravenous catheter so that the concentration of drug delivered per unit time can be more accurately assessed. Further, there are no problems associated with drug spillage, the handling of animals, or other confounding variables such as taste.

Original language	English (US)
Title of host publication	Methods in Drug Abuse Research
Subtitle of host publication	Cellular and Circuit Level Analyses
Publisher	CRC Press
Pages	17-50
Number of pages	34
ISBN (Electronic)	9781420038682
ISBN (Print)	0849323452, 9780849323454
State	Published - Jan 1 2002

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Medicine(all)
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

Fingerprint Dive into the research topics of 'Self-administration of drugs of abuse'. Together they form a unique fingerprint.

Cite this

Dworkin, S. I., & Stairs, D. J. (2002). Self-administration of drugs of abuse. In Methods in Drug Abuse Research: Cellular and Circuit Level Analyses (pp. 17-50). CRC Press.

@inbook{155312c7c6d442d6a1240c50c9ca6596,

title = "Self-administration of drugs of abuse",

abstract = "It has been over 40 years since the technical aspects of automatic intravenous drug delivery to rodents were described. 1 The development of self-administration methodology provided a tremendous technological advance for investigating drug abuse and resulted in clear demonstrations that the behavioral actions of psychoactive substances could be investigated using the same methods used to evaluate the reinforcing effects of nondrug reinforcers. The intravenous route of administration has several methodological advantages over other routes. The drug is discretely presented through an intravenous catheter so that the concentration of drug delivered per unit time can be more accurately assessed. Further, there are no problems associated with drug spillage, the handling of animals, or other confounding variables such as taste.",

author = "Dworkin, {Steven I.} and Stairs, {Dustin J.}",

year = "2002",

month = jan,

day = "1",

language = "English (US)",

isbn = "0849323452",

pages = "17--50",

booktitle = "Methods in Drug Abuse Research",

publisher = "CRC Press",

}

TY - CHAP

T1 - Self-administration of drugs of abuse

AU - Dworkin, Steven I.

AU - Stairs, Dustin J.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - It has been over 40 years since the technical aspects of automatic intravenous drug delivery to rodents were described. 1 The development of self-administration methodology provided a tremendous technological advance for investigating drug abuse and resulted in clear demonstrations that the behavioral actions of psychoactive substances could be investigated using the same methods used to evaluate the reinforcing effects of nondrug reinforcers. The intravenous route of administration has several methodological advantages over other routes. The drug is discretely presented through an intravenous catheter so that the concentration of drug delivered per unit time can be more accurately assessed. Further, there are no problems associated with drug spillage, the handling of animals, or other confounding variables such as taste.

AB - It has been over 40 years since the technical aspects of automatic intravenous drug delivery to rodents were described. 1 The development of self-administration methodology provided a tremendous technological advance for investigating drug abuse and resulted in clear demonstrations that the behavioral actions of psychoactive substances could be investigated using the same methods used to evaluate the reinforcing effects of nondrug reinforcers. The intravenous route of administration has several methodological advantages over other routes. The drug is discretely presented through an intravenous catheter so that the concentration of drug delivered per unit time can be more accurately assessed. Further, there are no problems associated with drug spillage, the handling of animals, or other confounding variables such as taste.

UR - http://www.scopus.com/inward/record.url?scp=40749112867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40749112867&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:40749112867

SN - 0849323452

SN - 9780849323454

SP - 17

EP - 50

BT - Methods in Drug Abuse Research

PB - CRC Press

ER -