Self-administration of drugs of abuse

Steven I. Dworkin, Dustin J. Stairs

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


It has been over 40 years since the technical aspects of automatic intravenous drug delivery to rodents were described. 1 The development of self-administration methodology provided a tremendous technological advance for investigating drug abuse and resulted in clear demonstrations that the behavioral actions of psychoactive substances could be investigated using the same methods used to evaluate the reinforcing effects of nondrug reinforcers. The intravenous route of administration has several methodological advantages over other routes. The drug is discretely presented through an intravenous catheter so that the concentration of drug delivered per unit time can be more accurately assessed. Further, there are no problems associated with drug spillage, the handling of animals, or other confounding variables such as taste.

Original languageEnglish (US)
Title of host publicationMethods in Drug Abuse Research
Subtitle of host publicationCellular and Circuit Level Analyses
PublisherCRC Press
Number of pages34
ISBN (Electronic)9781420038682
ISBN (Print)0849323452, 9780849323454
StatePublished - Jan 1 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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