Serum 25-hydroxyvitamin d concentrations ≥40 ng/ml are associated with >65% lower cancer risk

Pooled analysis of randomized trial and prospective cohort study

Sharon L. McDonnell, Carole Baggerly, Christine B. French, Leo L. Baggerly, Cedric F. Garland, Edward D. Gorham, Joan M. Lappe, Robert P. Heaney

Research output: Contribution to journalArticle

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Abstract

Background: Higher serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with a lower risk of multiple cancer types across a range of 25(OH)D concentrations. Objectives: To investigate whether the previously reported inverse association between 25(OH)D and cancer risk could be replicated, and if a 25(OH)D response region could be identified among women aged 55 years and older across a broad range of 25(OH)D concentrations. Methods: Data from two cohorts representing different median 25(OH)D concentrations were pooled to afford a broader range of 25(OH)D concentrations than either cohort alone: the Lappe cohort (N = 1,169), a randomized clinical trial cohort (median 25(OH)D = 30 ng/ml) and the GrassrootsHealth cohort (N = 1,135), a prospective cohort (median 25(OH)D = 48 ng/ml). Cancer incidence over a multi-year period (median: 3.9 years) was compared according to 25(OH)D concentration. Kaplan-Meier plots were developed and the association between 25(OH)D and cancer risk was examined with multivariate Cox regression using multiple 25 (OH)D measurements and spline functions. The study included all invasive cancers excluding skin cancer. Results: Age-adjusted cancer incidence across the combined cohort (N = 2,304) was 840 cases per 100,000 person-years (1,020 per 100,000 person-years in the Lappe cohort and 722 per 100,000 person-years in the GrassrootsHealth cohort). Incidence was lower at higher concentrations of 25(OH)D. Women with 25(OH)D concentrations ≥40 ng/ml had a 67% lower risk of cancer than women with concentrations

Original languageEnglish
Article numbere0152441
JournalPLoS One
Volume11
Issue number4
DOIs
StatePublished - Apr 1 2016

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risk analysis
Risk analysis
cohort studies
Cohort Studies
Prospective Studies
neoplasms
Serum
Neoplasms
Skin Neoplasms
Incidence
incidence
Splines
Skin
randomized clinical trials
Randomized Controlled Trials

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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McDonnell, S. L., Baggerly, C., French, C. B., Baggerly, L. L., Garland, C. F., Gorham, E. D., ... Heaney, R. P. (2016). Serum 25-hydroxyvitamin d concentrations ≥40 ng/ml are associated with >65% lower cancer risk: Pooled analysis of randomized trial and prospective cohort study. PLoS One, 11(4), [e0152441]. https://doi.org/10.1371/journal.pone.0152441

Serum 25-hydroxyvitamin d concentrations ≥40 ng/ml are associated with >65% lower cancer risk : Pooled analysis of randomized trial and prospective cohort study. / McDonnell, Sharon L.; Baggerly, Carole; French, Christine B.; Baggerly, Leo L.; Garland, Cedric F.; Gorham, Edward D.; Lappe, Joan M.; Heaney, Robert P.

In: PLoS One, Vol. 11, No. 4, e0152441, 01.04.2016.

Research output: Contribution to journalArticle

McDonnell, Sharon L. ; Baggerly, Carole ; French, Christine B. ; Baggerly, Leo L. ; Garland, Cedric F. ; Gorham, Edward D. ; Lappe, Joan M. ; Heaney, Robert P. / Serum 25-hydroxyvitamin d concentrations ≥40 ng/ml are associated with >65% lower cancer risk : Pooled analysis of randomized trial and prospective cohort study. In: PLoS One. 2016 ; Vol. 11, No. 4.
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