Serum and hair selenium levels in hereditary nonpolyposis colorectal cancer

Margaret A. Tempero, Maryce M. Jacobs, Henry T. Lynch, Curtis L. Graham, Alan J. Blotcky

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Since low selenium (Se) levels have been identified in some individuals with colon cancer, we evaluated Se levels as a potential marker for this malignancy in a kindred subject to hereditary nonpolyposis colorectal cancer, an autosomal dominant disease. Unaffected family members and spouses were selected randomly for testing. Serum Se levels were performed on dialyzed sera using the neutron activation technique. Hair Se assays were determined by a spectrofluorometric method. Family members were classified as having low, intermediate, or high risk for colon cancer based on family history. There was no correlation between serum and hair Se measurements. There was also no significant difference in hair or serum Se levels between any of the groups, suggesting that serum Se levels do not correlate with hereditary risk for colon cancer. Prospective studies are in progress to evaluate tissue Se levels and serial Se measurements in high risk patients to establish whether Se levels change with the development of colon cancer.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalBiological Trace Element Research
Volume6
Issue number1
DOIs
StatePublished - Feb 1 1984

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Inorganic Chemistry

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    Tempero, M. A., Jacobs, M. M., Lynch, H. T., Graham, C. L., & Blotcky, A. J. (1984). Serum and hair selenium levels in hereditary nonpolyposis colorectal cancer. Biological Trace Element Research, 6(1), 51-55. https://doi.org/10.1007/BF02918320