Serum vitamin D metabolites and calcium absorption in normal young and elderly free-living women and in women living in nursing homes

H. Karimi Kinyamu, John Christopher G. Gallagher, Kurt E. Balhorn, Kimberly M. Petranick, Karen A. Rafferty

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Vitamin D deficiency, which causes osteomalacia, may also be important in the pathogenesis of age-related osteoporosis. We studied serum vitamin D metabolites in 52 young women (mean age: 30 ± 3 y; range: 25-35 y), 64 elderly free-living women (mean age: 71 ± 4 y; range: 65-82 y) and 60 elderly women living in nursing homes (mean age: 84 ± 9 y; range: 61-102 y). Mean serum 25-hydroxyvitamin D (calcidiol) was 10.8 ± 4.4 nmol/L (27 ± 11 ng/mL) in women living in nursing homes and was similar to that of free- living young (11.3 ± 4.2 nmol/L, or 28 ± 10 ng/mL) and elderly (11.5 ± 3.2 nmol/L, or 29 ± 8 ng/mL) women. Vitamin D deficiency (defined as serum calcidiol <4.8 nmol/L, or 12 ng/mL) occurred in 8% of women living in nursing homes, in 6% of the young women, and in 1.6% of the free-living elderly women. Serum calcidiol was significantly correlated with vitamin D intake (r = 0.25, P <0.05) and inversely correlated with serum intact parathyroid hormone (iPTH) (r = -0.16, P <0.03). Serum iPTH increased with age and secondary hyperparathyroidism was observed in 17% of the women living in nursing homes. Calcium absorption declined with age, but calcium absorption and serum 1α,25-dihydroxyvitamin D (calcitriol) were significantly lower in women living in nursing homes, which probably contributed to the secondary hyperparathyroidism. In conclusion, normal serum calcidiol may avoid the problem of osteomalacia, but it does not correct malabsorption of calcium. Although calcitriol corrects the malabsorption of calcium, it remains to be seen whether higher amounts of vitamin D can normalize the calcium malabsorption of aging.

Original languageEnglish
Pages (from-to)790-797
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume65
Issue number3
StatePublished - 1997

Fingerprint

nursing homes
vitamin D
Nursing Homes
Vitamin D
metabolites
Calcium
calcium
25-hydroxycholecalciferol
Calcifediol
Serum
malabsorption
osteomalacia
hyperparathyroidism
vitamin D deficiency
calcitriol
Osteomalacia
Secondary Hyperparathyroidism
Vitamin D Deficiency
parathyroid hormone
Calcitriol

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Food Science

Cite this

Serum vitamin D metabolites and calcium absorption in normal young and elderly free-living women and in women living in nursing homes. / Kinyamu, H. Karimi; Gallagher, John Christopher G.; Balhorn, Kurt E.; Petranick, Kimberly M.; Rafferty, Karen A.

In: American Journal of Clinical Nutrition, Vol. 65, No. 3, 1997, p. 790-797.

Research output: Contribution to journalArticle

@article{2a56484d63084f98970e5091c5f3a3ee,
title = "Serum vitamin D metabolites and calcium absorption in normal young and elderly free-living women and in women living in nursing homes",
abstract = "Vitamin D deficiency, which causes osteomalacia, may also be important in the pathogenesis of age-related osteoporosis. We studied serum vitamin D metabolites in 52 young women (mean age: 30 ± 3 y; range: 25-35 y), 64 elderly free-living women (mean age: 71 ± 4 y; range: 65-82 y) and 60 elderly women living in nursing homes (mean age: 84 ± 9 y; range: 61-102 y). Mean serum 25-hydroxyvitamin D (calcidiol) was 10.8 ± 4.4 nmol/L (27 ± 11 ng/mL) in women living in nursing homes and was similar to that of free- living young (11.3 ± 4.2 nmol/L, or 28 ± 10 ng/mL) and elderly (11.5 ± 3.2 nmol/L, or 29 ± 8 ng/mL) women. Vitamin D deficiency (defined as serum calcidiol <4.8 nmol/L, or 12 ng/mL) occurred in 8{\%} of women living in nursing homes, in 6{\%} of the young women, and in 1.6{\%} of the free-living elderly women. Serum calcidiol was significantly correlated with vitamin D intake (r = 0.25, P <0.05) and inversely correlated with serum intact parathyroid hormone (iPTH) (r = -0.16, P <0.03). Serum iPTH increased with age and secondary hyperparathyroidism was observed in 17{\%} of the women living in nursing homes. Calcium absorption declined with age, but calcium absorption and serum 1α,25-dihydroxyvitamin D (calcitriol) were significantly lower in women living in nursing homes, which probably contributed to the secondary hyperparathyroidism. In conclusion, normal serum calcidiol may avoid the problem of osteomalacia, but it does not correct malabsorption of calcium. Although calcitriol corrects the malabsorption of calcium, it remains to be seen whether higher amounts of vitamin D can normalize the calcium malabsorption of aging.",
author = "Kinyamu, {H. Karimi} and Gallagher, {John Christopher G.} and Balhorn, {Kurt E.} and Petranick, {Kimberly M.} and Rafferty, {Karen A.}",
year = "1997",
language = "English",
volume = "65",
pages = "790--797",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "3",

}

TY - JOUR

T1 - Serum vitamin D metabolites and calcium absorption in normal young and elderly free-living women and in women living in nursing homes

AU - Kinyamu, H. Karimi

AU - Gallagher, John Christopher G.

AU - Balhorn, Kurt E.

AU - Petranick, Kimberly M.

AU - Rafferty, Karen A.

PY - 1997

Y1 - 1997

N2 - Vitamin D deficiency, which causes osteomalacia, may also be important in the pathogenesis of age-related osteoporosis. We studied serum vitamin D metabolites in 52 young women (mean age: 30 ± 3 y; range: 25-35 y), 64 elderly free-living women (mean age: 71 ± 4 y; range: 65-82 y) and 60 elderly women living in nursing homes (mean age: 84 ± 9 y; range: 61-102 y). Mean serum 25-hydroxyvitamin D (calcidiol) was 10.8 ± 4.4 nmol/L (27 ± 11 ng/mL) in women living in nursing homes and was similar to that of free- living young (11.3 ± 4.2 nmol/L, or 28 ± 10 ng/mL) and elderly (11.5 ± 3.2 nmol/L, or 29 ± 8 ng/mL) women. Vitamin D deficiency (defined as serum calcidiol <4.8 nmol/L, or 12 ng/mL) occurred in 8% of women living in nursing homes, in 6% of the young women, and in 1.6% of the free-living elderly women. Serum calcidiol was significantly correlated with vitamin D intake (r = 0.25, P <0.05) and inversely correlated with serum intact parathyroid hormone (iPTH) (r = -0.16, P <0.03). Serum iPTH increased with age and secondary hyperparathyroidism was observed in 17% of the women living in nursing homes. Calcium absorption declined with age, but calcium absorption and serum 1α,25-dihydroxyvitamin D (calcitriol) were significantly lower in women living in nursing homes, which probably contributed to the secondary hyperparathyroidism. In conclusion, normal serum calcidiol may avoid the problem of osteomalacia, but it does not correct malabsorption of calcium. Although calcitriol corrects the malabsorption of calcium, it remains to be seen whether higher amounts of vitamin D can normalize the calcium malabsorption of aging.

AB - Vitamin D deficiency, which causes osteomalacia, may also be important in the pathogenesis of age-related osteoporosis. We studied serum vitamin D metabolites in 52 young women (mean age: 30 ± 3 y; range: 25-35 y), 64 elderly free-living women (mean age: 71 ± 4 y; range: 65-82 y) and 60 elderly women living in nursing homes (mean age: 84 ± 9 y; range: 61-102 y). Mean serum 25-hydroxyvitamin D (calcidiol) was 10.8 ± 4.4 nmol/L (27 ± 11 ng/mL) in women living in nursing homes and was similar to that of free- living young (11.3 ± 4.2 nmol/L, or 28 ± 10 ng/mL) and elderly (11.5 ± 3.2 nmol/L, or 29 ± 8 ng/mL) women. Vitamin D deficiency (defined as serum calcidiol <4.8 nmol/L, or 12 ng/mL) occurred in 8% of women living in nursing homes, in 6% of the young women, and in 1.6% of the free-living elderly women. Serum calcidiol was significantly correlated with vitamin D intake (r = 0.25, P <0.05) and inversely correlated with serum intact parathyroid hormone (iPTH) (r = -0.16, P <0.03). Serum iPTH increased with age and secondary hyperparathyroidism was observed in 17% of the women living in nursing homes. Calcium absorption declined with age, but calcium absorption and serum 1α,25-dihydroxyvitamin D (calcitriol) were significantly lower in women living in nursing homes, which probably contributed to the secondary hyperparathyroidism. In conclusion, normal serum calcidiol may avoid the problem of osteomalacia, but it does not correct malabsorption of calcium. Although calcitriol corrects the malabsorption of calcium, it remains to be seen whether higher amounts of vitamin D can normalize the calcium malabsorption of aging.

UR - http://www.scopus.com/inward/record.url?scp=0031039718&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031039718&partnerID=8YFLogxK

M3 - Article

C2 - 9062531

AN - SCOPUS:0031039718

VL - 65

SP - 790

EP - 797

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -