Short-term down-regulation of the brain-specific, PtdIns(3,4,5)P 3/Ins(1,3,4,5)P4-binding, adapter protein, p42 IP4/centaurin-α1 in rat brain after acoustic and electric stimulation

G. Reiser, F. Striggow, C. Hackmann, H. Schwegler, D. M. Yilmazer-Hanke

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The protein p42IP4, expressed mainly in brain, specifically recognizes two second messenger molecules, Ins(1,3,4,5)P4 (IP 4), a water soluble metabolite of IP3 and the lipid PtdIns(3,4,5)P3 (PIP3), the product of the growth factor-activated enzyme PI-3-kinase. Here, we studied whether there is short-term regulation of the expression level of p42IP4 in limbic brain areas following acoustic and electric stimulation. The stimuli down-regulated the mRNA and protein levels within 2h in amygdala, hypothalamus and cingulate/retrospenial cortex. p42IP4 mRNA decreased by about 50% for about 24h, but recovered to control values after 72h. The present results are the first indication of a specific role of p42IP4 in the short-term regulation of a behavioral response. They indicate that p42 IP4, an adapter protein in PIP3-dependent cellular signaling, may play an important role in the signal transduction pathways regulating plasticity in neuronal cells.

Original languageEnglish (US)
Pages (from-to)89-93
Number of pages5
JournalNeurochemistry International
Issue number1
StatePublished - Jul 2004

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology


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