Short-term effects of nicotine on bone and calciotropic hormones in adult female rats

Yiu K. Fung, Mark G. Mendlik, Mary C. Haven, Mohammed P. Akhter, Donald B. Kimmel

Research output: Contribution to journalArticle

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Abstract

This study assessed the effects of two months nicotine treatment on bone formation and resorption end-points in adult, female rats. In addition, the concentrations of calciotropic hormones which included parathyroid hormone, calcitonin, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in rats (7 months old) were determined. All animals received either saline (n=7/group), nicotine (3.0 mg/kg/day) (n=7/group) or nicotine (4.5 mg/kg/day) (n=7/group) via subcutaneous implantation of osmotic minipumps containing either saline or nicotine for a period of two months. Serum, right tibia, left femur and lumbar vertebra (3-5) were collected for determination of hormonal concentrations as well as various parameters, including histomorphometry, bone mineral density, bone mineral content and vertebral strength. Although nicotine-treated rats showed a lower level of 25-hydroxyvitamin D [54.4±3.1 ng/ml for the 3.0 mg/kg/day and 55.8±2.8 for the 4.5 mg/kg/day group] (mean±S.E.M.) as compared to controls (74.8±2.8 ng/ml) (P

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalPharmacology and Toxicology
Volume82
Issue number5
StatePublished - 1998

Fingerprint

Nicotine
Rats
Bone
Hormones
Bone and Bones
Bone Density
Minerals
Lumbar Vertebrae
Calcitonin
Bone Resorption
Parathyroid Hormone
Tibia
Osteogenesis
Femur
Animals
Serum
25-hydroxyvitamin D

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Fung, Y. K., Mendlik, M. G., Haven, M. C., Akhter, M. P., & Kimmel, D. B. (1998). Short-term effects of nicotine on bone and calciotropic hormones in adult female rats. Pharmacology and Toxicology, 82(5), 243-249.

Short-term effects of nicotine on bone and calciotropic hormones in adult female rats. / Fung, Yiu K.; Mendlik, Mark G.; Haven, Mary C.; Akhter, Mohammed P.; Kimmel, Donald B.

In: Pharmacology and Toxicology, Vol. 82, No. 5, 1998, p. 243-249.

Research output: Contribution to journalArticle

Fung, YK, Mendlik, MG, Haven, MC, Akhter, MP & Kimmel, DB 1998, 'Short-term effects of nicotine on bone and calciotropic hormones in adult female rats', Pharmacology and Toxicology, vol. 82, no. 5, pp. 243-249.
Fung, Yiu K. ; Mendlik, Mark G. ; Haven, Mary C. ; Akhter, Mohammed P. ; Kimmel, Donald B. / Short-term effects of nicotine on bone and calciotropic hormones in adult female rats. In: Pharmacology and Toxicology. 1998 ; Vol. 82, No. 5. pp. 243-249.
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