Silver-mediated synthesis of indolizines via oxidative C-H functionalization and 5-endo-dig cyclization

Amit N. Pandya; James T. Fletcher; Eric M. Villa; Devendra K. Agrawal

doi:10.1016/j.tetlet.2014.10.112

Silver-mediated synthesis of indolizines via oxidative C-H functionalization and 5-endo-dig cyclization

Amit N. Pandya, James T. Fletcher, Eric M. Villa, Devendra K. Agrawal

Department of Chemistry

Research output: Contribution to journal › Article

19 Scopus citations

Abstract

An efficient strategy for the synthesis of indolizines from readily available starting materials via oxidative C-H functionalization and 5-endo-dig cyclization in one step has been demonstrated. This protocol represents wide substrate scope, high functional group tolerance, and selectivity. The structure of the product was confirmed by X-ray crystallographic studies. Ag₂CO₃ required of this tandem reaction can be recycled and reused after undergoing oxidative reaction.

Original language	English (US)
Pages (from-to)	6922-6924
Number of pages	3
Journal	Tetrahedron Letters
Volume	55
Issue number	50
DOIs	https://doi.org/10.1016/j.tetlet.2014.10.112
State	Published - Dec 10 2014

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All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Pandya, A. N., Fletcher, J. T., Villa, E. M., & Agrawal, D. K. (2014). Silver-mediated synthesis of indolizines via oxidative C-H functionalization and 5-endo-dig cyclization. Tetrahedron Letters, 55(50), 6922-6924. https://doi.org/10.1016/j.tetlet.2014.10.112

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10.1016/j.tetlet.2014.10.112