Silver-mediated synthesis of indolizines via oxidative C-H functionalization and 5-endo-dig cyclization

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

An efficient strategy for the synthesis of indolizines from readily available starting materials via oxidative C-H functionalization and 5-endo-dig cyclization in one step has been demonstrated. This protocol represents wide substrate scope, high functional group tolerance, and selectivity. The structure of the product was confirmed by X-ray crystallographic studies. Ag2CO3 required of this tandem reaction can be recycled and reused after undergoing oxidative reaction.

Original languageEnglish
Pages (from-to)6922-6924
Number of pages3
JournalTetrahedron Letters
Volume55
Issue number50
DOIs
StatePublished - Dec 10 2014

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Indolizines
Cyclization
Silver
Functional groups
X-Rays
X rays
Substrates

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Silver-mediated synthesis of indolizines via oxidative C-H functionalization and 5-endo-dig cyclization. / Pandya, Amit N.; Fletcher, James T.; Villa, Eric; Agrawal, Devendra K.

In: Tetrahedron Letters, Vol. 55, No. 50, 10.12.2014, p. 6922-6924.

Research output: Contribution to journalArticle

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