Silver-mediated synthesis of indolizines via oxidative C-H functionalization and 5-endo-dig cyclization

Amit N. Pandya, James T. Fletcher, Eric M. Villa, Devendra K. Agrawal

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Abstract

An efficient strategy for the synthesis of indolizines from readily available starting materials via oxidative C-H functionalization and 5-endo-dig cyclization in one step has been demonstrated. This protocol represents wide substrate scope, high functional group tolerance, and selectivity. The structure of the product was confirmed by X-ray crystallographic studies. Ag2CO3 required of this tandem reaction can be recycled and reused after undergoing oxidative reaction.

Original languageEnglish (US)
Pages (from-to)6922-6924
Number of pages3
JournalTetrahedron Letters
Volume55
Issue number50
DOIs
StatePublished - Dec 10 2014

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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