Silver-mediated synthesis of indolizines via oxidative C-H functionalization and 5-endo-dig cyclization

Amit N. Pandya; James T. Fletcher; Eric M. Villa; Devendra K. Agrawal

doi:10.1016/j.tetlet.2014.10.112

Silver-mediated synthesis of indolizines via oxidative C-H functionalization and 5-endo-dig cyclization

Amit N. Pandya, James T. Fletcher, Eric M. Villa, Devendra K. Agrawal

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

An efficient strategy for the synthesis of indolizines from readily available starting materials via oxidative C-H functionalization and 5-endo-dig cyclization in one step has been demonstrated. This protocol represents wide substrate scope, high functional group tolerance, and selectivity. The structure of the product was confirmed by X-ray crystallographic studies. Ag₂CO₃ required of this tandem reaction can be recycled and reused after undergoing oxidative reaction.

Original language	English (US)
Pages (from-to)	6922-6924
Number of pages	3
Journal	Tetrahedron Letters
Volume	55
Issue number	50
DOIs	https://doi.org/10.1016/j.tetlet.2014.10.112
State	Published - Dec 10 2014

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Silver-mediated synthesis of indolizines via oxidative C-H functionalization and 5-endo-dig cyclization",

abstract = "An efficient strategy for the synthesis of indolizines from readily available starting materials via oxidative C-H functionalization and 5-endo-dig cyclization in one step has been demonstrated. This protocol represents wide substrate scope, high functional group tolerance, and selectivity. The structure of the product was confirmed by X-ray crystallographic studies. Ag2CO3 required of this tandem reaction can be recycled and reused after undergoing oxidative reaction.",

author = "Pandya, {Amit N.} and Fletcher, {James T.} and Villa, {Eric M.} and Agrawal, {Devendra K.}",

note = "Funding Information: This work was supported by research grants R01HL104516 and R01HL120659 from the National Institutes of Health , USA to DK Agrawal. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. ",

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T1 - Silver-mediated synthesis of indolizines via oxidative C-H functionalization and 5-endo-dig cyclization

AU - Pandya, Amit N.

AU - Fletcher, James T.

AU - Villa, Eric M.

AU - Agrawal, Devendra K.

N1 - Funding Information: This work was supported by research grants R01HL104516 and R01HL120659 from the National Institutes of Health , USA to DK Agrawal. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

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N2 - An efficient strategy for the synthesis of indolizines from readily available starting materials via oxidative C-H functionalization and 5-endo-dig cyclization in one step has been demonstrated. This protocol represents wide substrate scope, high functional group tolerance, and selectivity. The structure of the product was confirmed by X-ray crystallographic studies. Ag2CO3 required of this tandem reaction can be recycled and reused after undergoing oxidative reaction.

AB - An efficient strategy for the synthesis of indolizines from readily available starting materials via oxidative C-H functionalization and 5-endo-dig cyclization in one step has been demonstrated. This protocol represents wide substrate scope, high functional group tolerance, and selectivity. The structure of the product was confirmed by X-ray crystallographic studies. Ag2CO3 required of this tandem reaction can be recycled and reused after undergoing oxidative reaction.

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