Sirtuins: a conserved key unlocking AceCS activity

Brian J. North, David A. Sinclair

Research output: Contribution to journalShort surveypeer-review

51 Scopus citations


Bacterial acetyl-coenzyme A (acetyl-CoA) synthetase (AceCS), an evolutionarily conserved enzyme that converts acetate to acetyl-CoA, is activated by sirtuin-mediated deacetylation. Two recent studies show that this mechanism of regulation is also crucial for mammalian AceCS activity, indicating that control of metabolism at the step of converting acetate to acetyl-CoA is conserved. These findings highlight a metabolic regulatory network controlled by sirtuins that has implications for the mechanisms of calorie restriction and modulation of mammalian lifespan.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalTrends in Biochemical Sciences
Issue number1
StatePublished - Jan 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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