Site specific bone adaptation response to mechanical loading

S. J. Kuruvilla, S. D. Fox, D. M. Cullen, Mohammed P. Akhter

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Over 25 million Americans suffer from osteoporosis. Bone size and strength depends both upon the level of adaptation due to physical activity (applied load), and genetics. We hypothesized that bone adaptation to loads differs among mice breeds and bone sites. Forty-five adult female mice from three inbred strains (C57BL/6 [B6], C3H/HeJ [C3], and DBA/2J [D2]) were loaded at the right tibia and ulna in vivo with non-invasive loading devices. Each loading session consisted of 99 cycles at a force range that induced ∼2000 microstrain (μ)̇at the mid-shaft of the tibia (2.5 to 3.5 N force) and ulna (1.5 to 2 N force). The right and left ulnae and tibiae were collected and processed using protocols for histological undecalcified cortical bone slides. Standard histomorphometry techniques were used to quantify new bone formation. The histomorphometric variables include percentage mineralizing surface (%MS), mineral apposition rate (MAR), and bone formation rate (BFR). Net loading response [right-left limb] was compared between different breeds at tibial and ulnar sites using two-way ANOVA with repeated measures (p

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalJournal of Musculoskeletal Neuronal Interactions
Volume8
Issue number1
StatePublished - Mar 2008

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Ulna
Tibia
Osteogenesis
Bone and Bones
Genetic Load
Inbred Strains Mice
Osteoporosis
Minerals
Analysis of Variance
Extremities
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Endocrinology

Cite this

Site specific bone adaptation response to mechanical loading. / Kuruvilla, S. J.; Fox, S. D.; Cullen, D. M.; Akhter, Mohammed P.

In: Journal of Musculoskeletal Neuronal Interactions, Vol. 8, No. 1, 03.2008, p. 71-78.

Research output: Contribution to journalArticle

Kuruvilla, S. J. ; Fox, S. D. ; Cullen, D. M. ; Akhter, Mohammed P. / Site specific bone adaptation response to mechanical loading. In: Journal of Musculoskeletal Neuronal Interactions. 2008 ; Vol. 8, No. 1. pp. 71-78.
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