Skin blood flow abnormalities in diabetic dermopathy

Alexandra Brugler, Shaun Thompson, Scott Turner, Binh Ngo, Marc Rendell

Research output: Contribution to journalArticle

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Abstract

Background: Diabetic dermopathy is the most common specific cutaneous finding in diabetes. Objective: Using laser Doppler technology, we tested the hypothesis that diabetic dermopathy arises from abnormal local skin blood flow. Methods: We measured cutaneous blood flow in patients with type 1 diabetes without dermopathy and compared values with those in a control group of patients with type 1 diabetes without diabetic dermopathy and in a nondiabetic group. We measured at 3 separate sites on the pretibial area on the legs of each participant, at dermopathy lesions, and at a number of standard sites on the upper and lower extremities. Results: We studied 25 patients with diabetes and diabetic dermopathy, average age 51 ± 2 years, mean duration of diabetes 28 ± 3 years. In all, 58 patients with type 1 diabetes without diabetic dermopathy served as control patients, average age 41 ± 2 years, mean duration of diabetes 23 ± 2 years. There were 67 nondiabetic control subjects, average age 47 ± 3 years. The patients with diabetic dermopathy showed a marked reduction in skin blood flow at 35°C at normal-appearing skin areas on the pretibial surface of the legs (1.1 ± 0.1 mL/min/100 g) compared with 1.7 ± 0.1 mL/min/100 g (P =.01) in the type 1 diabetic control group and 2.1 ± 0.3 mL/min/100 g (P

Original languageEnglish (US)
Pages (from-to)559-563
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume65
Issue number3
DOIs
StatePublished - Sep 1 2011

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All Science Journal Classification (ASJC) codes

  • Dermatology

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