Smoking and bone metabolism in elderly women

P. B. Rapuri, John Christopher G. Gallagher, K. E. Balhorn, K. L. Ryschon

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Cigarette smoking has been implicated as a risk factor for osteoporosis. In the present study, the relationship between smoking and bone mineral density, calcitropic hormones, calcium absorption, and biochemical indices related to bone and mineral metabolism was examined at baseline, in subjects recruited for an osteoporotic study. The subjects included 489 elderly women, aged 65-77 years. After exclusions (thiazide users), 54 women constituted the smoking group and 390 women were classified as nonsmokers. The effect of frequency of smoking was also examined in this population (33 light smokers [ <1 pack/day] and 21 heavy smokers [ > 1 pack/day]). Adjusted mean total body bone mineral density was 4% lower (0.968 ± 0.019 vs. 1.009 ± 0.004) and the total hip density was 6% lower (0.778 ± 0.024 vs. 0.826 ± 0.006) in heavy smokers compared with nonsmokers. At the other sites measured (spine, midradius, femoral neck, trochanter, and Ward's triangle), a similar nonsignificant trend was observed. The adjusted mean calcium absorption corrected for weight was lower (13%) both in light and heavy smokers compared with nonsmokers, and serum 25-hydroxyvitamin D was significantly lower (16%) in heavy smokers than nonsmokers. Serum parathryroid hormone (PTH) was higher in heavy smokers, but was not significantly different from that of nonsmokers. A significant increase in bone remodeling markers, serum osteocalcin (4.35 ± 0.271 vs. 3.79 ± 0.066) and urine N- telopeptide/creatinine (NTx/Cr) ratio (74.5 ± 5.75 vs. 49.8 ± 1.4) was seen in heavy smokers compared with nonsmokers. These results suggest that smoking lowers bone mineral density, and is a result of decreased calcium absorption associated with secondary hyperparathyroidism and increased bone resorption. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)429-436
Number of pages8
JournalBone
Volume27
Issue number3
DOIs
StatePublished - Sep 2000

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Smoking
Bone and Bones
Bone Density
Calcium
Hormones
Thiazides
Secondary Hyperparathyroidism
Bone Remodeling
Femur Neck
Osteocalcin
Bone Resorption
Serum
Femur
Osteoporosis
Minerals
Hip
Creatinine
Spine
Biomarkers
Urine

All Science Journal Classification (ASJC) codes

  • Physiology
  • Hematology

Cite this

Rapuri, P. B., Gallagher, J. C. G., Balhorn, K. E., & Ryschon, K. L. (2000). Smoking and bone metabolism in elderly women. Bone, 27(3), 429-436. https://doi.org/10.1016/S8756-3282(00)00341-0

Smoking and bone metabolism in elderly women. / Rapuri, P. B.; Gallagher, John Christopher G.; Balhorn, K. E.; Ryschon, K. L.

In: Bone, Vol. 27, No. 3, 09.2000, p. 429-436.

Research output: Contribution to journalArticle

Rapuri, PB, Gallagher, JCG, Balhorn, KE & Ryschon, KL 2000, 'Smoking and bone metabolism in elderly women', Bone, vol. 27, no. 3, pp. 429-436. https://doi.org/10.1016/S8756-3282(00)00341-0
Rapuri, P. B. ; Gallagher, John Christopher G. ; Balhorn, K. E. ; Ryschon, K. L. / Smoking and bone metabolism in elderly women. In: Bone. 2000 ; Vol. 27, No. 3. pp. 429-436.
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