Smoking and the risk of breast cancer among carriers of BRCA mutations

Parviz Ghadiriani, Jan Lubinski, Henry T. Lynch, Susan L. Neuhausen, Barbara Weber, Claudine Isaacs, Ruth Gershoni Baruch, Susan Randall, Peter Ainsworth, Eitan Freidman, Douglas Horsman, Patricia Tonin, William D. Foulkes, Nadine Tung, Ping Sun, Steven A. Narod

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The effect of cigarette smoking on the risk of breast cancer is controversial, although most studies show little or no effect. It has been suggested that smoking may reduce the risk of developing hereditary breast cancer. We completed a case-control study on 1,097 women with breast cancer who were BRCA1 or BRCA2 mutation carriers and 1,097 age-matched controls with a mutation in the same gene but without breast cancer. There were no statistically significant differences between the cases and controls in terms of the number of current and ex-smokers (41.2% and 40.4%, respectively) or the age at smoking commencement (18.2 years and 18.5 years, respectively). There were no statistically significant differences between cases and controls regarding beginning smoking within 5 years of menarche (OR = 1.03; 95% CI 0.83 to 1.28) or before the first pregnancy (OR = 1.09; 95% CI = 0.90 to 1.33). In conclusion, contrary to our previous report, smoking does not appear to be a risk factor for breast cancer among carriers of BRCA mutations.

Original languageEnglish
Pages (from-to)413-416
Number of pages4
JournalInternational Journal of Cancer
Volume110
Issue number3
DOIs
StatePublished - Jun 20 2004

Fingerprint

Smoking
Breast Neoplasms
Mutation
Menarche
Case-Control Studies
Pregnancy
Genes

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Ghadiriani, P., Lubinski, J., Lynch, H. T., Neuhausen, S. L., Weber, B., Isaacs, C., ... Narod, S. A. (2004). Smoking and the risk of breast cancer among carriers of BRCA mutations. International Journal of Cancer, 110(3), 413-416. https://doi.org/10.1002/ijc.20106

Smoking and the risk of breast cancer among carriers of BRCA mutations. / Ghadiriani, Parviz; Lubinski, Jan; Lynch, Henry T.; Neuhausen, Susan L.; Weber, Barbara; Isaacs, Claudine; Baruch, Ruth Gershoni; Randall, Susan; Ainsworth, Peter; Freidman, Eitan; Horsman, Douglas; Tonin, Patricia; Foulkes, William D.; Tung, Nadine; Sun, Ping; Narod, Steven A.

In: International Journal of Cancer, Vol. 110, No. 3, 20.06.2004, p. 413-416.

Research output: Contribution to journalArticle

Ghadiriani, P, Lubinski, J, Lynch, HT, Neuhausen, SL, Weber, B, Isaacs, C, Baruch, RG, Randall, S, Ainsworth, P, Freidman, E, Horsman, D, Tonin, P, Foulkes, WD, Tung, N, Sun, P & Narod, SA 2004, 'Smoking and the risk of breast cancer among carriers of BRCA mutations', International Journal of Cancer, vol. 110, no. 3, pp. 413-416. https://doi.org/10.1002/ijc.20106
Ghadiriani P, Lubinski J, Lynch HT, Neuhausen SL, Weber B, Isaacs C et al. Smoking and the risk of breast cancer among carriers of BRCA mutations. International Journal of Cancer. 2004 Jun 20;110(3):413-416. https://doi.org/10.1002/ijc.20106
Ghadiriani, Parviz ; Lubinski, Jan ; Lynch, Henry T. ; Neuhausen, Susan L. ; Weber, Barbara ; Isaacs, Claudine ; Baruch, Ruth Gershoni ; Randall, Susan ; Ainsworth, Peter ; Freidman, Eitan ; Horsman, Douglas ; Tonin, Patricia ; Foulkes, William D. ; Tung, Nadine ; Sun, Ping ; Narod, Steven A. / Smoking and the risk of breast cancer among carriers of BRCA mutations. In: International Journal of Cancer. 2004 ; Vol. 110, No. 3. pp. 413-416.
@article{4eb3f3a70a8244f98f562a19b0dd4986,
title = "Smoking and the risk of breast cancer among carriers of BRCA mutations",
abstract = "The effect of cigarette smoking on the risk of breast cancer is controversial, although most studies show little or no effect. It has been suggested that smoking may reduce the risk of developing hereditary breast cancer. We completed a case-control study on 1,097 women with breast cancer who were BRCA1 or BRCA2 mutation carriers and 1,097 age-matched controls with a mutation in the same gene but without breast cancer. There were no statistically significant differences between the cases and controls in terms of the number of current and ex-smokers (41.2{\%} and 40.4{\%}, respectively) or the age at smoking commencement (18.2 years and 18.5 years, respectively). There were no statistically significant differences between cases and controls regarding beginning smoking within 5 years of menarche (OR = 1.03; 95{\%} CI 0.83 to 1.28) or before the first pregnancy (OR = 1.09; 95{\%} CI = 0.90 to 1.33). In conclusion, contrary to our previous report, smoking does not appear to be a risk factor for breast cancer among carriers of BRCA mutations.",
author = "Parviz Ghadiriani and Jan Lubinski and Lynch, {Henry T.} and Neuhausen, {Susan L.} and Barbara Weber and Claudine Isaacs and Baruch, {Ruth Gershoni} and Susan Randall and Peter Ainsworth and Eitan Freidman and Douglas Horsman and Patricia Tonin and Foulkes, {William D.} and Nadine Tung and Ping Sun and Narod, {Steven A.}",
year = "2004",
month = "6",
day = "20",
doi = "10.1002/ijc.20106",
language = "English",
volume = "110",
pages = "413--416",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Smoking and the risk of breast cancer among carriers of BRCA mutations

AU - Ghadiriani, Parviz

AU - Lubinski, Jan

AU - Lynch, Henry T.

AU - Neuhausen, Susan L.

AU - Weber, Barbara

AU - Isaacs, Claudine

AU - Baruch, Ruth Gershoni

AU - Randall, Susan

AU - Ainsworth, Peter

AU - Freidman, Eitan

AU - Horsman, Douglas

AU - Tonin, Patricia

AU - Foulkes, William D.

AU - Tung, Nadine

AU - Sun, Ping

AU - Narod, Steven A.

PY - 2004/6/20

Y1 - 2004/6/20

N2 - The effect of cigarette smoking on the risk of breast cancer is controversial, although most studies show little or no effect. It has been suggested that smoking may reduce the risk of developing hereditary breast cancer. We completed a case-control study on 1,097 women with breast cancer who were BRCA1 or BRCA2 mutation carriers and 1,097 age-matched controls with a mutation in the same gene but without breast cancer. There were no statistically significant differences between the cases and controls in terms of the number of current and ex-smokers (41.2% and 40.4%, respectively) or the age at smoking commencement (18.2 years and 18.5 years, respectively). There were no statistically significant differences between cases and controls regarding beginning smoking within 5 years of menarche (OR = 1.03; 95% CI 0.83 to 1.28) or before the first pregnancy (OR = 1.09; 95% CI = 0.90 to 1.33). In conclusion, contrary to our previous report, smoking does not appear to be a risk factor for breast cancer among carriers of BRCA mutations.

AB - The effect of cigarette smoking on the risk of breast cancer is controversial, although most studies show little or no effect. It has been suggested that smoking may reduce the risk of developing hereditary breast cancer. We completed a case-control study on 1,097 women with breast cancer who were BRCA1 or BRCA2 mutation carriers and 1,097 age-matched controls with a mutation in the same gene but without breast cancer. There were no statistically significant differences between the cases and controls in terms of the number of current and ex-smokers (41.2% and 40.4%, respectively) or the age at smoking commencement (18.2 years and 18.5 years, respectively). There were no statistically significant differences between cases and controls regarding beginning smoking within 5 years of menarche (OR = 1.03; 95% CI 0.83 to 1.28) or before the first pregnancy (OR = 1.09; 95% CI = 0.90 to 1.33). In conclusion, contrary to our previous report, smoking does not appear to be a risk factor for breast cancer among carriers of BRCA mutations.

UR - http://www.scopus.com/inward/record.url?scp=2442528555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442528555&partnerID=8YFLogxK

U2 - 10.1002/ijc.20106

DO - 10.1002/ijc.20106

M3 - Article

C2 - 15095307

AN - SCOPUS:2442528555

VL - 110

SP - 413

EP - 416

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 3

ER -