Smoking and the risk of breast cancer among carriers of BRCA mutations

Parviz Ghadiriani, Jan Lubinski, Henry Lynch, Susan L. Neuhausen, Barbara Weber, Claudine Isaacs, Ruth Gershoni Baruch, Susan Randall, Peter Ainsworth, Eitan Freidman, Douglas Horsman, Patricia Tonin, William D. Foulkes, Nadine Tung, Ping Sun, Steven A. Narod

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39 Scopus citations

Abstract

The effect of cigarette smoking on the risk of breast cancer is controversial, although most studies show little or no effect. It has been suggested that smoking may reduce the risk of developing hereditary breast cancer. We completed a case-control study on 1,097 women with breast cancer who were BRCA1 or BRCA2 mutation carriers and 1,097 age-matched controls with a mutation in the same gene but without breast cancer. There were no statistically significant differences between the cases and controls in terms of the number of current and ex-smokers (41.2% and 40.4%, respectively) or the age at smoking commencement (18.2 years and 18.5 years, respectively). There were no statistically significant differences between cases and controls regarding beginning smoking within 5 years of menarche (OR = 1.03; 95% CI 0.83 to 1.28) or before the first pregnancy (OR = 1.09; 95% CI = 0.90 to 1.33). In conclusion, contrary to our previous report, smoking does not appear to be a risk factor for breast cancer among carriers of BRCA mutations.

Original languageEnglish (US)
Pages (from-to)413-416
Number of pages4
JournalInternational Journal of Cancer
Volume110
Issue number3
DOIs
StatePublished - Jun 20 2004

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ghadiriani, P., Lubinski, J., Lynch, H., Neuhausen, S. L., Weber, B., Isaacs, C., Baruch, R. G., Randall, S., Ainsworth, P., Freidman, E., Horsman, D., Tonin, P., Foulkes, W. D., Tung, N., Sun, P., & Narod, S. A. (2004). Smoking and the risk of breast cancer among carriers of BRCA mutations. International Journal of Cancer, 110(3), 413-416. https://doi.org/10.1002/ijc.20106