Soil binds prions and influences their biologic properties

S. L. Bartelt-Hunt, S. E. Saunders, J. C. Bartz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The prion protein is believed to be the causative agent of a host of fatal neurodegenerative diseases, including chronic wasting disease and scrapie. The prion protein is shed into the environment and is strongly bound to soil. Evidence suggests that binding to soil can influence the biologic properties of the prion protein, including prion replication and infectivity. The physicochemical properties of soil influence this behavior, and some evidence suggests that local soil type may play a role in prion disease transmission in the environment.

Original languageEnglish (US)
Title of host publicationProteins at Interfaces III State of the Art
PublisherAmerican Chemical Society
Pages433-452
Number of pages20
ISBN (Print)9780841227965
DOIs
StatePublished - Dec 12 2012

Publication series

NameACS Symposium Series
Volume1120
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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  • Cite this

    Bartelt-Hunt, S. L., Saunders, S. E., & Bartz, J. C. (2012). Soil binds prions and influences their biologic properties. In Proteins at Interfaces III State of the Art (pp. 433-452). (ACS Symposium Series; Vol. 1120). American Chemical Society. https://doi.org/10.1021/bk-2012-1120.ch020