TY - JOUR
T1 - Soil-mediated prion transmission
T2 - Is local soil-type a key determinant of prion disease incidence?
AU - Saunders, Samuel E.
AU - Bartz, Jason C.
AU - Bartelt-Hunt, Shannon L.
N1 - Funding Information:
This work was supported by the USDA/APHIS/Wildlife Services/National Wildlife Research Center; the National Center for Research Resources (P20 RR0115635-6, C06 RR17417-01 and G20RR024001); and the National Institute for Neurological Disorders and Stroke (2R01 NS052609).
PY - 2012/5
Y1 - 2012/5
N2 - Prion diseases, including chronic wasting disease (CWD) and scrapie, can be transmitted via indirect environmental routes. Animals habitually ingest soil, and results from laboratory experiments demonstrate prions can bind to a wide range of soils and soil minerals, retain the ability to replicate, and remain infectious, indicating soil could serve as a reservoir for natural prion transmission and a potential prion exposure route for humans. Preliminary epidemiological modeling suggests soil texture may influence the incidence of prion disease. These results are supported by experimental work demonstrating variance in prion interactions with soil, including variance in prion soil adsorption and soil-bound prion replication with respect to soil type. Thus, local soil type may be a key determinant of prion incidence. Further experimental and epidemiological work is required to fully elucidate the dynamics of soil-mediated prion transmission, an effort that should lead to effective disease management and mitigation strategies.
AB - Prion diseases, including chronic wasting disease (CWD) and scrapie, can be transmitted via indirect environmental routes. Animals habitually ingest soil, and results from laboratory experiments demonstrate prions can bind to a wide range of soils and soil minerals, retain the ability to replicate, and remain infectious, indicating soil could serve as a reservoir for natural prion transmission and a potential prion exposure route for humans. Preliminary epidemiological modeling suggests soil texture may influence the incidence of prion disease. These results are supported by experimental work demonstrating variance in prion interactions with soil, including variance in prion soil adsorption and soil-bound prion replication with respect to soil type. Thus, local soil type may be a key determinant of prion incidence. Further experimental and epidemiological work is required to fully elucidate the dynamics of soil-mediated prion transmission, an effort that should lead to effective disease management and mitigation strategies.
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U2 - 10.1016/j.chemosphere.2011.12.076
DO - 10.1016/j.chemosphere.2011.12.076
M3 - Review article
C2 - 22265680
AN - SCOPUS:84858621370
VL - 87
SP - 661
EP - 667
JO - Chemosphere
JF - Chemosphere
SN - 0045-6535
IS - 7
ER -