TY - JOUR
T1 - Something's gotta give
T2 - How PCNA alters its structure in response to mutations and the implications on cellular processes
AU - Dieckman, Lynne
N1 - Funding Information:
This work was supported by the National Institutes of Health [grant number 2P20-GM103427-19 ]; the Creighton University Center for Undergraduate Research and Scholarship; and the Creighton University Dr. George F. Haddix President’s Faculty Research Fund .
Publisher Copyright:
© 2020
PY - 2021/8
Y1 - 2021/8
N2 - Proliferating cell nuclear antigen (PCNA) is an essential protein that regulates the systematic recruitment and activity of proteins in a multitude of biochemical processes. Very few proteins, if any, bear similar responsibilities to those of PCNA, and its list of roles only continues to expand. However, even as one of the most well-studied proteins in research, many questions still remain about the complex quaternary structure and function of PCNA. Over the last forty years, we have gained a considerable amount of insight from studying amino acid substitutions within the protein. The combination of phenotypic and structural information about mutant PCNA proteins has shed light on the incredibly dynamic and accommodating nature of this important protein and why it stands at the crossroads of DNA metabolic pathways.
AB - Proliferating cell nuclear antigen (PCNA) is an essential protein that regulates the systematic recruitment and activity of proteins in a multitude of biochemical processes. Very few proteins, if any, bear similar responsibilities to those of PCNA, and its list of roles only continues to expand. However, even as one of the most well-studied proteins in research, many questions still remain about the complex quaternary structure and function of PCNA. Over the last forty years, we have gained a considerable amount of insight from studying amino acid substitutions within the protein. The combination of phenotypic and structural information about mutant PCNA proteins has shed light on the incredibly dynamic and accommodating nature of this important protein and why it stands at the crossroads of DNA metabolic pathways.
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U2 - 10.1016/j.pbiomolbio.2020.10.008
DO - 10.1016/j.pbiomolbio.2020.10.008
M3 - Article
C2 - 33161058
AN - SCOPUS:85096520619
VL - 163
SP - 46
EP - 59
JO - Progress in Biophysics and Molecular Biology
JF - Progress in Biophysics and Molecular Biology
SN - 0079-6107
ER -