Source of extracellular brain adenosine during hypoxia in fetal sheep

Brian J. Koos; Lawrence Kruger; Thomas F. Murray

doi:10.1016/S0006-8993(97)01207-9

Source of extracellular brain adenosine during hypoxia in fetal sheep

Brian J. Koos, Lawrence Kruger, Thomas F. Murray

Research output: Contribution to journal › Article

32 Scopus citations

Abstract

Microdialysis was performed to determine whether hypoxia increases fetal brain adenosine (ADO) concentration through dephosphorylation of extracellular 5'-adenosine monophosphate (5-AMP). Hypoxia (fetal PaO₂ ≃ 14 Torr) increased fetal brain ADO levels ~ two-fold when the probes were perfused with synthetic cerebrospinal fluid (CSF) containing inhibitors of the nucleoside transporter but not with this solution plus a blocker of ecto- 5'-nucleotidase (AOPCP). The hypoxia-induced rise in fetal brain ADO concentrations depends critically upon the hydrolysis of extracellular 5'- AMP.

Original language	English (US)
Pages (from-to)	439-442
Number of pages	4
Journal	Brain Research
Volume	778
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(97)01207-9
State	Published - Dec 19 1997
Externally published	Yes

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All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Cite this

Koos, B. J., Kruger, L., & Murray, T. F. (1997). Source of extracellular brain adenosine during hypoxia in fetal sheep. Brain Research, 778(2), 439-442. https://doi.org/10.1016/S0006-8993(97)01207-9

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Access to Document

10.1016/S0006-8993(97)01207-9