Source of extracellular brain adenosine during hypoxia in fetal sheep

Brian J. Koos, Lawrence Kruger, Thomas F. Murray

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Microdialysis was performed to determine whether hypoxia increases fetal brain adenosine (ADO) concentration through dephosphorylation of extracellular 5'-adenosine monophosphate (5-AMP). Hypoxia (fetal PaO2 ≃ 14 Torr) increased fetal brain ADO levels ~ two-fold when the probes were perfused with synthetic cerebrospinal fluid (CSF) containing inhibitors of the nucleoside transporter but not with this solution plus a blocker of ecto- 5'-nucleotidase (AOPCP). The hypoxia-induced rise in fetal brain ADO concentrations depends critically upon the hydrolysis of extracellular 5'- AMP.

Original languageEnglish (US)
Pages (from-to)439-442
Number of pages4
JournalBrain Research
Issue number2
StatePublished - Dec 19 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


Dive into the research topics of 'Source of extracellular brain adenosine during hypoxia in fetal sheep'. Together they form a unique fingerprint.

Cite this