Specific sides to multifaceted glycosaminoglycans are observed in embryonic development

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Ubiquitously found in the extracellular matrix and attached to the surface of most cells, glycosaminoglycans (GAGs) mediate many intercellular interactions. Originally described in 1889 as the primary carbohydrate in cartilage and then in 1916 as a coagulation inhibitor from liver, various GAGs have since been identified as key regulators of normal physiology. GAGs are critical mediators of differentiation, migration, tissue morphogenesis, and organogenesis during embryonic development. While GAGs are simple polysaccharide chains, many GAGs acquire a considerable degree of complexity by extensive modifications involving sulfation and epimerization. Embryos that lack specific GAG modifying enzymes have distinct developmental defects, illuminating the importance of GAG complexity. Revealing how these complex molecules specifically function in the embryo has often required additional approaches, the results of which suggest that GAG modifications might instructively mediate embryonic development.

Original languageEnglish
Pages (from-to)631-637
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume21
Issue number6
DOIs
StatePublished - Aug 2010
Externally publishedYes

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Glycosaminoglycans
Embryonic Development
Embryonic Structures
Organogenesis
Morphogenesis
Cartilage
Extracellular Matrix
Polysaccharides
Carbohydrates
Liver
Enzymes

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Developmental Biology

Cite this

Specific sides to multifaceted glycosaminoglycans are observed in embryonic development. / Kramer, Ken.

In: Seminars in Cell and Developmental Biology, Vol. 21, No. 6, 08.2010, p. 631-637.

Research output: Contribution to journalReview article

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