Spotlight on reteplase in thrombotic occlusive disorders

Dene Simpson, M. A A Siddiqui, Lesley J. Scott, Daniel E. Hilleman

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Reteplase (Retavase®) is a plasminogen activator, mimicking endogenous tissue plasminogen activator (t-PA), a serine protease, converting plasminogen to plasmin and thereby precipitating thrombolysis. It is a thirdgeneration recombinant form of t-PA that operates in the presence of fibrin (i.e. it is fibrin specific). Reteplase can be administered as a bolus dose (nonweight-based), rather than an infusion, which promotes rapid and safe administration. The ease of administration of this reteplase dosage regimen (two 10U bolus doses, each over 2 minutes, 30 minutes apart) is conducive to prehospital initiation of thrombolytic treatment in patients with ST-segment elevation myocardial infarction (STEMI), which reduces the time to treatment, a critical factor in improving long-term survival. In large randomized clinical trials of patients with STEMI, reteplase was superior to alteplase for coronary artery patency (according to TIMI [thrombolysis in myocardial infarction] flow) at 60 and 90 minutes, but there was no significant difference between agents for mortality rate and incidence of intracranial bleeding. The 35-day mortality rates were equivalent for reteplase and streptokinase recipients; there was reduced incidence of some cardiac events with reteplase versus streptokinase, but a greater incidence of hemorrhagic stroke. Reteplase has also shown thrombolytic efficacy (in nonapproved indications) as a catheter-directed intraarterial or intravenous infusion for peripheral vessel occlusions, as 5-minute bolus doses (in 1U increments) for acute ischemic stroke, as a low-dose solution for occluded catheters or grafts, and as an intravenous double bolus for massive pulmonary embolism. Across studies in these indications, the incidence of bleeding complications associated with reteplase treatment appeared to be similar to that associated with other fibrin-specific thrombolytic agents. With its efficacy, and the ease of administration of the bolus doses potentially minimizing dosage errors when treatment is administered under time pressure, reteplase is a valuable option for pre- or in-hospital thrombolytic treatment in patients with STEMI, and is a useful thrombolytic for the treatment of the other thrombotic occlusive disorders described.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalBioDrugs
Volume21
Issue number1
DOIs
StatePublished - 2007

Fingerprint

Tissue Plasminogen Activator
Fibrin
Streptokinase
Myocardial Infarction
Incidence
Therapeutics
Catheters
Stroke
reteplase
Hemorrhage
Intra Arterial Infusions
Fibrinolytic Agents
Mortality
Plasminogen Activators
Plasminogen
Fibrinolysin
Serine Proteases
Pulmonary Embolism
Intravenous Infusions
Coronary Vessels

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Spotlight on reteplase in thrombotic occlusive disorders. / Simpson, Dene; Siddiqui, M. A A; Scott, Lesley J.; Hilleman, Daniel E.

In: BioDrugs, Vol. 21, No. 1, 2007, p. 65-68.

Research output: Contribution to journalReview article

Simpson, Dene ; Siddiqui, M. A A ; Scott, Lesley J. ; Hilleman, Daniel E. / Spotlight on reteplase in thrombotic occlusive disorders. In: BioDrugs. 2007 ; Vol. 21, No. 1. pp. 65-68.
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