Stability of SIV gp32 fusion-peptide single-layer protofibrils as monitored by molecular-dynamics simulations

Patricia Soto, Josep Cladera, Alan E. Mark, Xavier Daura

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Modeling the mechanisms of protofibril twisting: Molecular-dynamics simulations of simian viral peptide aggregates show that β sheets of 10 to 30 chains form left-handed helical ribbons with saddlelike curvature (see picture). These structures are highly dynamic, with oscillations around an average twist angle of 9-10°, and a pitch of 15-20 nm, depending on β-sheet length. The peptides studied are key to viral entry into host cells.

Original languageEnglish
Pages (from-to)1065-1067
Number of pages3
JournalAngewandte Chemie - International Edition
Volume44
Issue number7
DOIs
StatePublished - Feb 4 2005
Externally publishedYes

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Peptides
Molecular dynamics
Fusion reactions
Computer simulation

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Stability of SIV gp32 fusion-peptide single-layer protofibrils as monitored by molecular-dynamics simulations. / Soto, Patricia; Cladera, Josep; Mark, Alan E.; Daura, Xavier.

In: Angewandte Chemie - International Edition, Vol. 44, No. 7, 04.02.2005, p. 1065-1067.

Research output: Contribution to journalArticle

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