Statins as antiarrhythmics

A systematic review part I: Effects on risk of atrial fibrillation

Hussam Abuissa, James H. O'Keefe, Kevin A. Bybee

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Background: Recent studies have demonstrated that statins may possess antiarrhythmic properties in addition to their lipid-lowering effects. Methods: Studies which reported the association of statins with the incidence of atrial arrhythmias were identified through a systematic review of published literature. Results: One randomized, placebo-controlled trial of 200 patients undergoing cardiac surgery showed that atorvastatin decreased the incidence of postoperative atrial fibrillation by 61%. Observational studies in patients with stable coronary disease, left ventricular dysfunction, or those undergoing cardiac or noncardiac surgery show that statin therapy is associated with an approximately 50% lower rate of atrial fibrillation. Two small randomized trials reported conflicting results: one showing that atorvastatin reduced the recurrence of AF after electrical cardioversion and the other finding that pravastatin did not. Conclusions: Published data suggests that statins may possess antiarrhythmic properties that reduce the propensity for atrial fibrillation. Most of this data is observational; more randomized, placebo-controlled trials are needed.

Original languageEnglish
Pages (from-to)544-548
Number of pages5
JournalClinical Cardiology
Volume32
Issue number10
DOIs
StatePublished - 2009
Externally publishedYes

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Atrial Fibrillation
Randomized Controlled Trials
Placebos
Pravastatin
Electric Countershock
Incidence
Left Ventricular Dysfunction
Thoracic Surgery
Observational Studies
Coronary Disease
Cardiac Arrhythmias
Lipids
Recurrence
Atorvastatin Calcium
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Statins as antiarrhythmics : A systematic review part I: Effects on risk of atrial fibrillation. / Abuissa, Hussam; O'Keefe, James H.; Bybee, Kevin A.

In: Clinical Cardiology, Vol. 32, No. 10, 2009, p. 544-548.

Research output: Contribution to journalReview article

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