Abstract
Background: Recent studies have demonstrated that statins may possess antiarrhythmic properties in addition to their lipid-lowering effects. Methods: Studies which reported the association of statins with the incidence of ventricular arrhythmias were identified through a systematic review of the published literature. Results: Statins have been associated with significant reduction in ventricular arrhythmia in cardiomyopathy patients with an implantable cardioverter defibrillator, although randomized trials have not been completed. Conclusions: Published data suggest that statins may possess antiarrhythmic properties that reduce the propensity for ventricular arrhythmias. Most of this data is observational; more randomized, placebo-controlled trials are needed.
| Original language | English |
|---|---|
| Pages (from-to) | 549-552 |
| Number of pages | 4 |
| Journal | Clinical Cardiology |
| Volume | 32 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2009 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Statins as antiarrhythmics : A systematic review part II: Effects on risk of ventricular arrhythmias. / Abuissa, Hussam; O'Keefe, James H.; Bybee, Kevin A.
In: Clinical Cardiology, Vol. 32, No. 10, 2009, p. 549-552.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Statins as antiarrhythmics
T2 - A systematic review part II: Effects on risk of ventricular arrhythmias
AU - Abuissa, Hussam
AU - O'Keefe, James H.
AU - Bybee, Kevin A.
PY - 2009
Y1 - 2009
N2 - Background: Recent studies have demonstrated that statins may possess antiarrhythmic properties in addition to their lipid-lowering effects. Methods: Studies which reported the association of statins with the incidence of ventricular arrhythmias were identified through a systematic review of the published literature. Results: Statins have been associated with significant reduction in ventricular arrhythmia in cardiomyopathy patients with an implantable cardioverter defibrillator, although randomized trials have not been completed. Conclusions: Published data suggest that statins may possess antiarrhythmic properties that reduce the propensity for ventricular arrhythmias. Most of this data is observational; more randomized, placebo-controlled trials are needed.
AB - Background: Recent studies have demonstrated that statins may possess antiarrhythmic properties in addition to their lipid-lowering effects. Methods: Studies which reported the association of statins with the incidence of ventricular arrhythmias were identified through a systematic review of the published literature. Results: Statins have been associated with significant reduction in ventricular arrhythmia in cardiomyopathy patients with an implantable cardioverter defibrillator, although randomized trials have not been completed. Conclusions: Published data suggest that statins may possess antiarrhythmic properties that reduce the propensity for ventricular arrhythmias. Most of this data is observational; more randomized, placebo-controlled trials are needed.
UR - http://www.scopus.com/inward/record.url?scp=70849132546&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70849132546&partnerID=8YFLogxK
U2 - 10.1002/clc.20435
DO - 10.1002/clc.20435
M3 - Review article
C2 - 19816987
AN - SCOPUS:70849132546
VL - 32
SP - 549
EP - 552
JO - Clinical Cardiology
JF - Clinical Cardiology
SN - 0160-9289
IS - 10
ER -