Stimulation of bone formation in vivo by phosphate supplementation

W. H. Harris, R. P. Heaney, L. A. Davis, E. H. Weinberg, R. D. Coutts, A. L. Schiller

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The effect of phosphate supplementation on bone remodeling was assessed in six mature, healthy beagle dogs. The phosphate supplement was given in divided doses orally, daily for 12 weeks in the form of a neutral potassium phosphate preparation. The dose averaged 108 mg P/kg per day, which is double the normal canine phosphorus intake. Bone remodeling was assessed by measurement, at sacrifice, of areas of cortical bone containing different colorcoded tetracyclines which had been continuously administered during 12-week control and treatment periods; remodeling was assessed kinetically during the control and treatment periods by replicate studies employing47Ca intravenously. Both techniques demonstrated that the principal effect of phosphate supplementation was a significant stimulation of bone formation. Within cortical bone, formation was doubled, from an average of 2.7% to 5.3% per year. The major location of new bone deposits was endosteal. Whole skeletal mineral accretion, measured kinetically, increased 45% above an average control value of 0.154 g/day. These studies suggest that, in the adult dog, "normal" plasma phosphate levels are suboptimal for new bone formation. Even with this short duration of administration, phosphate produced microscopic calcification of the renal parenchyma. However, there was no biochemical evidence of renal functional impairment.

Original languageEnglish
Pages (from-to)85-98
Number of pages14
JournalCalcified Tissue Research
Volume22
Issue number1
DOIs
StatePublished - Dec 1977

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Osteogenesis
Phosphates
Bone Remodeling
Dogs
Kidney
Tetracyclines
Phosphorus
Minerals
Canidae
Bone and Bones
Cortical Bone

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

Harris, W. H., Heaney, R. P., Davis, L. A., Weinberg, E. H., Coutts, R. D., & Schiller, A. L. (1977). Stimulation of bone formation in vivo by phosphate supplementation. Calcified Tissue Research, 22(1), 85-98. https://doi.org/10.1007/BF02010349

Stimulation of bone formation in vivo by phosphate supplementation. / Harris, W. H.; Heaney, R. P.; Davis, L. A.; Weinberg, E. H.; Coutts, R. D.; Schiller, A. L.

In: Calcified Tissue Research, Vol. 22, No. 1, 12.1977, p. 85-98.

Research output: Contribution to journalArticle

Harris, WH, Heaney, RP, Davis, LA, Weinberg, EH, Coutts, RD & Schiller, AL 1977, 'Stimulation of bone formation in vivo by phosphate supplementation', Calcified Tissue Research, vol. 22, no. 1, pp. 85-98. https://doi.org/10.1007/BF02010349
Harris WH, Heaney RP, Davis LA, Weinberg EH, Coutts RD, Schiller AL. Stimulation of bone formation in vivo by phosphate supplementation. Calcified Tissue Research. 1977 Dec;22(1):85-98. https://doi.org/10.1007/BF02010349
Harris, W. H. ; Heaney, R. P. ; Davis, L. A. ; Weinberg, E. H. ; Coutts, R. D. ; Schiller, A. L. / Stimulation of bone formation in vivo by phosphate supplementation. In: Calcified Tissue Research. 1977 ; Vol. 22, No. 1. pp. 85-98.
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