Studying inner ear protein-protein interactions using FRET and FLIM

Richard J. Hallworth, Benjamin Currall, Michael G. Nichols, Xudong Wu, Jian Zuo

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Molecular genetic studies of the inner ear have recently revealed a large number of previously undescribed proteins, but their functions remain unclear. Optical methods such as FRET and FLIM are just beginning to be applied to the study of functional interactions between novel inner ear proteins. This review discusses the various methods for employing FRET and FLIM in protein-protein interaction studies, their advantages and pitfalls, with examples drawn from inner ear studies.

Original languageEnglish
Pages (from-to)122-131
Number of pages10
JournalBrain Research
Volume1091
Issue number1
DOIs
Publication statusPublished - May 26 2006

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

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