Abstract
Objective The lipid excipients of the self-emulsifying drug delivery systems (SEDDS) could play a role in interfering with the drug precipitation to maintain its supersaturation, a step with possible major significance on the SEDDS. Thus, the effect of lipid chain length on indomethacin precipitation rate from SEDDS upon dilution was studied. Method Indomethacin SEDDS were prepared using medium and long chain lipids at 5% and 13% (w/w) drug load. Two medium chain lipids Lauroglycol and Capryol, and two long chain lipids Labrafil and castor oil, were studied. The 13% w/w SEDDS were evaluated for drug release, and the physicochemical properties of the precipitated drug were characterized by PXRD, DSC, IR and Raman. Key findings The final optimized SEDDS consisted of Lauroglycol (lipid): Transcutol (co-solvent): Labrasol (surfactant). No precipitate was observed with long chain lipids SEDDS, whereas medium chain lipids SEDDS showed precipitation within 30 min of drug release from 13% w/w formulations. Precipitation studies showed that the medium chain lipids resulted in a modified indomethacin form possibly an ester. The ester formation signifies the interaction between indomethacin and medium chain length lipids. Conclusions The study emphasizes the importance of lipids chain length of excipients in successful SEDDS formulations. The study provides insight into the underlying drug lipid interactions in SEDDS formulations.
| Original language | English |
|---|---|
| Pages (from-to) | 1134-1144 |
| Number of pages | 11 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 65 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2013 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmaceutical Science
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Studying the effect of lipid chain length on the precipitation of a poorly water soluble drug from self-emulsifying drug delivery system on dispersion into aqueous medium. / Prasad, Dev; Chauhan, Harsh; Atef, Eman.
In: Journal of Pharmacy and Pharmacology, Vol. 65, No. 8, 08.2013, p. 1134-1144.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Studying the effect of lipid chain length on the precipitation of a poorly water soluble drug from self-emulsifying drug delivery system on dispersion into aqueous medium
AU - Prasad, Dev
AU - Chauhan, Harsh
AU - Atef, Eman
PY - 2013/8
Y1 - 2013/8
N2 - Objective The lipid excipients of the self-emulsifying drug delivery systems (SEDDS) could play a role in interfering with the drug precipitation to maintain its supersaturation, a step with possible major significance on the SEDDS. Thus, the effect of lipid chain length on indomethacin precipitation rate from SEDDS upon dilution was studied. Method Indomethacin SEDDS were prepared using medium and long chain lipids at 5% and 13% (w/w) drug load. Two medium chain lipids Lauroglycol and Capryol, and two long chain lipids Labrafil and castor oil, were studied. The 13% w/w SEDDS were evaluated for drug release, and the physicochemical properties of the precipitated drug were characterized by PXRD, DSC, IR and Raman. Key findings The final optimized SEDDS consisted of Lauroglycol (lipid): Transcutol (co-solvent): Labrasol (surfactant). No precipitate was observed with long chain lipids SEDDS, whereas medium chain lipids SEDDS showed precipitation within 30 min of drug release from 13% w/w formulations. Precipitation studies showed that the medium chain lipids resulted in a modified indomethacin form possibly an ester. The ester formation signifies the interaction between indomethacin and medium chain length lipids. Conclusions The study emphasizes the importance of lipids chain length of excipients in successful SEDDS formulations. The study provides insight into the underlying drug lipid interactions in SEDDS formulations.
AB - Objective The lipid excipients of the self-emulsifying drug delivery systems (SEDDS) could play a role in interfering with the drug precipitation to maintain its supersaturation, a step with possible major significance on the SEDDS. Thus, the effect of lipid chain length on indomethacin precipitation rate from SEDDS upon dilution was studied. Method Indomethacin SEDDS were prepared using medium and long chain lipids at 5% and 13% (w/w) drug load. Two medium chain lipids Lauroglycol and Capryol, and two long chain lipids Labrafil and castor oil, were studied. The 13% w/w SEDDS were evaluated for drug release, and the physicochemical properties of the precipitated drug were characterized by PXRD, DSC, IR and Raman. Key findings The final optimized SEDDS consisted of Lauroglycol (lipid): Transcutol (co-solvent): Labrasol (surfactant). No precipitate was observed with long chain lipids SEDDS, whereas medium chain lipids SEDDS showed precipitation within 30 min of drug release from 13% w/w formulations. Precipitation studies showed that the medium chain lipids resulted in a modified indomethacin form possibly an ester. The ester formation signifies the interaction between indomethacin and medium chain length lipids. Conclusions The study emphasizes the importance of lipids chain length of excipients in successful SEDDS formulations. The study provides insight into the underlying drug lipid interactions in SEDDS formulations.
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U2 - 10.1111/jphp.12077
DO - 10.1111/jphp.12077
M3 - Article
VL - 65
SP - 1134
EP - 1144
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 8
ER -