Successful unrelated cord blood transplantation for homozygous α-thalassemia

Burak Gumuscu, Elizabeth I. Thompson, Alfred C. Grovas, Terence L. Zach, Phyllis I. Warkentin, Peter F. Coccia

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A now 10-year-old Laotian female was delivered at 30-week gestation by cesarean section because of severe hydrops. Fetal blood sampling revealed homozygous α-thalassemia. After immediate resuscitation, the infant was supported with frequent red cell transfusions. At 44 months of age, she received a 5 of 6 human leukocyte antigen-matched unrelated cord blood transplantation. She was treated with phlebotomy and chelation therapy with Deferasirox for correction of hemosiderosis and has been transfusion-independent since 41 days after transplant. She is currently 6 years after transplantation with stable, 100% donor engraftment, resolved iron overload, and normal growth and development.

Original languageEnglish
Pages (from-to)570-572
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume35
Issue number7
DOIs
StatePublished - Oct 2013

Fingerprint

Thalassemia
Fetal Blood
Transplantation
Hemosiderosis
Chelation Therapy
Iron Overload
Phlebotomy
HLA Antigens
Growth and Development
Resuscitation
Cesarean Section
Edema
Tissue Donors
Transplants
Pregnancy
deferasirox

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Successful unrelated cord blood transplantation for homozygous α-thalassemia. / Gumuscu, Burak; Thompson, Elizabeth I.; Grovas, Alfred C.; Zach, Terence L.; Warkentin, Phyllis I.; Coccia, Peter F.

In: Journal of Pediatric Hematology/Oncology, Vol. 35, No. 7, 10.2013, p. 570-572.

Research output: Contribution to journalArticle

Gumuscu, Burak ; Thompson, Elizabeth I. ; Grovas, Alfred C. ; Zach, Terence L. ; Warkentin, Phyllis I. ; Coccia, Peter F. / Successful unrelated cord blood transplantation for homozygous α-thalassemia. In: Journal of Pediatric Hematology/Oncology. 2013 ; Vol. 35, No. 7. pp. 570-572.
@article{71ad7ed531294e6db61c6b9f7fc39918,
title = "Successful unrelated cord blood transplantation for homozygous α-thalassemia",
abstract = "A now 10-year-old Laotian female was delivered at 30-week gestation by cesarean section because of severe hydrops. Fetal blood sampling revealed homozygous α-thalassemia. After immediate resuscitation, the infant was supported with frequent red cell transfusions. At 44 months of age, she received a 5 of 6 human leukocyte antigen-matched unrelated cord blood transplantation. She was treated with phlebotomy and chelation therapy with Deferasirox for correction of hemosiderosis and has been transfusion-independent since 41 days after transplant. She is currently 6 years after transplantation with stable, 100{\%} donor engraftment, resolved iron overload, and normal growth and development.",
author = "Burak Gumuscu and Thompson, {Elizabeth I.} and Grovas, {Alfred C.} and Zach, {Terence L.} and Warkentin, {Phyllis I.} and Coccia, {Peter F.}",
year = "2013",
month = "10",
doi = "10.1097/MPH.0b013e31827e7f6a",
language = "English",
volume = "35",
pages = "570--572",
journal = "Journal of Pediatric Hematology/Oncology",
issn = "1077-4114",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Successful unrelated cord blood transplantation for homozygous α-thalassemia

AU - Gumuscu, Burak

AU - Thompson, Elizabeth I.

AU - Grovas, Alfred C.

AU - Zach, Terence L.

AU - Warkentin, Phyllis I.

AU - Coccia, Peter F.

PY - 2013/10

Y1 - 2013/10

N2 - A now 10-year-old Laotian female was delivered at 30-week gestation by cesarean section because of severe hydrops. Fetal blood sampling revealed homozygous α-thalassemia. After immediate resuscitation, the infant was supported with frequent red cell transfusions. At 44 months of age, she received a 5 of 6 human leukocyte antigen-matched unrelated cord blood transplantation. She was treated with phlebotomy and chelation therapy with Deferasirox for correction of hemosiderosis and has been transfusion-independent since 41 days after transplant. She is currently 6 years after transplantation with stable, 100% donor engraftment, resolved iron overload, and normal growth and development.

AB - A now 10-year-old Laotian female was delivered at 30-week gestation by cesarean section because of severe hydrops. Fetal blood sampling revealed homozygous α-thalassemia. After immediate resuscitation, the infant was supported with frequent red cell transfusions. At 44 months of age, she received a 5 of 6 human leukocyte antigen-matched unrelated cord blood transplantation. She was treated with phlebotomy and chelation therapy with Deferasirox for correction of hemosiderosis and has been transfusion-independent since 41 days after transplant. She is currently 6 years after transplantation with stable, 100% donor engraftment, resolved iron overload, and normal growth and development.

UR - http://www.scopus.com/inward/record.url?scp=84885182279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885182279&partnerID=8YFLogxK

U2 - 10.1097/MPH.0b013e31827e7f6a

DO - 10.1097/MPH.0b013e31827e7f6a

M3 - Article

C2 - 23337553

AN - SCOPUS:84885182279

VL - 35

SP - 570

EP - 572

JO - Journal of Pediatric Hematology/Oncology

JF - Journal of Pediatric Hematology/Oncology

SN - 1077-4114

IS - 7

ER -