Abstract
The existence of high-affinity [3H]-imipramine recognition sites was demonstrated in membranes prepared from the cerebral cortex, hypothalamus and platelets obtained from fawn-hooded rats. The Bmax and Kd values for [3H]-imipramine binding to cerebral cortical membranes were virtually identical to thos obtained with cortical membrane preparations of Sprague-Dawley rats. An NBR strain of rats, genetically related to fawn-hooded rats, was found to have significantly higher levels of [3H]-imipramine binding sites in cerebral cortical membranes when compared to fawn-hooded and Sprague-Dawley rats. All four strains of rats examined possessed extremely high densities of [3H]-imipramine binding sites in a purified platelet membrane fraction. These results do not support the finding of others that the cerebral cortex and platelets of fawn-hooded rats are virtually devoid of [3H]-imipramine binding sites.
Original language | English (US) |
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Pages (from-to) | 781-784 |
Number of pages | 4 |
Journal | Neuropharmacology |
Volume | 22 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1983 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pharmacology
- Cellular and Molecular Neuroscience