Abstract
During its second meeting at Amsterdam in 1990, the International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) decided to carry out a pilot study on colorectal cancer surveillance in HNPCC. The objectives of the study were to ascertain in each of the participating centers the number of HNPCC families, the recommended screening procedures, the age at diagnosis of colorectal cancer (CRC), and the occurrence of interval cancers. Nine centers in seven countries including Denmark, Finland, Italy, Japan, The Netherlands, Switzerland, and the United States participated. Data were derived from a total of 165 families. With respect to screening, half of the centers advise colonoscopy as the only procedure. The interval between the consecutive examinations varies from one to three years. In the majority of the centers, screening begins at 20 to 25 years. Lifelong screening is recommended by three centers, while the rest advise discontinuation at age 60 to 75 years. The family material included 840 patients with colorectal cancer. The mean age at diagnosis was 45 years, and about 15 percent were diagnosed at age 60 or later. A total of 682 high-risk relatives are being followed. After the follow-up of 1 to 10 years in these families, only six cases of interval cancers were encountered.
| Original language | English |
|---|---|
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | Diseases of the Colon and Rectum |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1993 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
Cite this
Surveillance in hereditary nonpolyposis colorectal cancer : An international cooperative study of 165 families. / Vasen, Hans F.; Mecklin, Jukka Pekka; Watson, Patrice; Utsunomiya, Joji; Bertario, Lucio; Lynch, Patrick; Svendsen, Lars B.; Cristofaro, Giuseppe; Müller, Hansjakob; Khan, P. Meera; Lynch, Henry T.
In: Diseases of the Colon and Rectum, Vol. 36, No. 1, 01.1993, p. 1-4.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Surveillance in hereditary nonpolyposis colorectal cancer
T2 - An international cooperative study of 165 families
AU - Vasen, Hans F.
AU - Mecklin, Jukka Pekka
AU - Watson, Patrice
AU - Utsunomiya, Joji
AU - Bertario, Lucio
AU - Lynch, Patrick
AU - Svendsen, Lars B.
AU - Cristofaro, Giuseppe
AU - Müller, Hansjakob
AU - Khan, P. Meera
AU - Lynch, Henry T.
PY - 1993/1
Y1 - 1993/1
N2 - During its second meeting at Amsterdam in 1990, the International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) decided to carry out a pilot study on colorectal cancer surveillance in HNPCC. The objectives of the study were to ascertain in each of the participating centers the number of HNPCC families, the recommended screening procedures, the age at diagnosis of colorectal cancer (CRC), and the occurrence of interval cancers. Nine centers in seven countries including Denmark, Finland, Italy, Japan, The Netherlands, Switzerland, and the United States participated. Data were derived from a total of 165 families. With respect to screening, half of the centers advise colonoscopy as the only procedure. The interval between the consecutive examinations varies from one to three years. In the majority of the centers, screening begins at 20 to 25 years. Lifelong screening is recommended by three centers, while the rest advise discontinuation at age 60 to 75 years. The family material included 840 patients with colorectal cancer. The mean age at diagnosis was 45 years, and about 15 percent were diagnosed at age 60 or later. A total of 682 high-risk relatives are being followed. After the follow-up of 1 to 10 years in these families, only six cases of interval cancers were encountered.
AB - During its second meeting at Amsterdam in 1990, the International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) decided to carry out a pilot study on colorectal cancer surveillance in HNPCC. The objectives of the study were to ascertain in each of the participating centers the number of HNPCC families, the recommended screening procedures, the age at diagnosis of colorectal cancer (CRC), and the occurrence of interval cancers. Nine centers in seven countries including Denmark, Finland, Italy, Japan, The Netherlands, Switzerland, and the United States participated. Data were derived from a total of 165 families. With respect to screening, half of the centers advise colonoscopy as the only procedure. The interval between the consecutive examinations varies from one to three years. In the majority of the centers, screening begins at 20 to 25 years. Lifelong screening is recommended by three centers, while the rest advise discontinuation at age 60 to 75 years. The family material included 840 patients with colorectal cancer. The mean age at diagnosis was 45 years, and about 15 percent were diagnosed at age 60 or later. A total of 682 high-risk relatives are being followed. After the follow-up of 1 to 10 years in these families, only six cases of interval cancers were encountered.
UR - http://www.scopus.com/inward/record.url?scp=0027518250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027518250&partnerID=8YFLogxK
U2 - 10.1007/BF02050292
DO - 10.1007/BF02050292
M3 - Article
C2 - 8416772
AN - SCOPUS:0027518250
VL - 36
SP - 1
EP - 4
JO - Diseases of the Colon and Rectum
JF - Diseases of the Colon and Rectum
SN - 0012-3706
IS - 1
ER -