Surveillance in Lynch syndrome: How aggressive?

Stephen J. Lanspa, J. X. Jenkins, R. J. Cavalieri, T. C. Smyrk, P. Watson, J. Lynch, Henry T. Lynch

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Objective: To identify colorectal cancers occurring after colonoscopic screening in patients at risk for Lynch syndrome. Methods: All cancers in Lynch syndrome families on file at the Creighton University Hereditary Cancer Institute were reviewed for history of prior colonoscopy. Results: Of 225 individuals with 313 colon cancers, six patients from different families had colon cancers arising within 4 1/2 yr of colonoscopic surveillance. Another 17 patients had metachronous colon cancers within 5 yr of resection of their first colon cancer. Conclusion: Of 225 colorectal cancer patients from Lynch syndrome families, 10.2% of patients had colorectal cancer within 5 yr of colonoscopy or colon resection. In Lynch syndrome, the potential for interval neoplasms and the malignant potential of missed diminutive adenomas may differ from cases in the general population.

Original languageEnglish
Pages (from-to)1978-1980
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume89
Issue number11
StatePublished - 1994

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Hereditary Nonpolyposis Colorectal Neoplasms
Colonic Neoplasms
Colorectal Neoplasms
Colonoscopy
Neoplasms
Adenoma
Colon
Population

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Lanspa, S. J., Jenkins, J. X., Cavalieri, R. J., Smyrk, T. C., Watson, P., Lynch, J., & Lynch, H. T. (1994). Surveillance in Lynch syndrome: How aggressive? American Journal of Gastroenterology, 89(11), 1978-1980.

Surveillance in Lynch syndrome : How aggressive? / Lanspa, Stephen J.; Jenkins, J. X.; Cavalieri, R. J.; Smyrk, T. C.; Watson, P.; Lynch, J.; Lynch, Henry T.

In: American Journal of Gastroenterology, Vol. 89, No. 11, 1994, p. 1978-1980.

Research output: Contribution to journalArticle

Lanspa, SJ, Jenkins, JX, Cavalieri, RJ, Smyrk, TC, Watson, P, Lynch, J & Lynch, HT 1994, 'Surveillance in Lynch syndrome: How aggressive?', American Journal of Gastroenterology, vol. 89, no. 11, pp. 1978-1980.
Lanspa SJ, Jenkins JX, Cavalieri RJ, Smyrk TC, Watson P, Lynch J et al. Surveillance in Lynch syndrome: How aggressive? American Journal of Gastroenterology. 1994;89(11):1978-1980.
Lanspa, Stephen J. ; Jenkins, J. X. ; Cavalieri, R. J. ; Smyrk, T. C. ; Watson, P. ; Lynch, J. ; Lynch, Henry T. / Surveillance in Lynch syndrome : How aggressive?. In: American Journal of Gastroenterology. 1994 ; Vol. 89, No. 11. pp. 1978-1980.
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abstract = "Objective: To identify colorectal cancers occurring after colonoscopic screening in patients at risk for Lynch syndrome. Methods: All cancers in Lynch syndrome families on file at the Creighton University Hereditary Cancer Institute were reviewed for history of prior colonoscopy. Results: Of 225 individuals with 313 colon cancers, six patients from different families had colon cancers arising within 4 1/2 yr of colonoscopic surveillance. Another 17 patients had metachronous colon cancers within 5 yr of resection of their first colon cancer. Conclusion: Of 225 colorectal cancer patients from Lynch syndrome families, 10.2{\%} of patients had colorectal cancer within 5 yr of colonoscopy or colon resection. In Lynch syndrome, the potential for interval neoplasms and the malignant potential of missed diminutive adenomas may differ from cases in the general population.",
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