Susceptibility to coxsackievirus B3-induced chronic myocarditis maps near the murine Tcrα and Myhcα loci on chromosome 14

Monica D. Traystman, Lawrence H. Chow, Bruce M. McManus, Ahvie Herskowitz, Muriel N. Nesbitt, Kirk Beisel

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study was undertaken to determine the genetic control of host susceptibility to coxsackievirus B3 (CVB3)-induced chronic myocarditis in a mouse model. An autosomal recessive autoimmune myocardial disease (amd) gene (possibly more than one gene), which determined susceptibility to CVB3-induced chronic myocarditis in the A/J and DBA/2J inbred mouse strains, was mapped to a segment of chromosome 14. Data from both the AXB/BXA recombinant inbred (RI) strains and the B10.D2(57N) H-8b congenic mice supported this linkage relationship. Analysis of the AXB/BXA RI strain distribution patterns suggested that amd maps distal to the Np-2, Tcrα, and Myhcα loci.

Original languageEnglish
Pages (from-to)721-726
Number of pages6
JournalAmerican Journal of Pathology
Volume138
Issue number3
StatePublished - Mar 1991
Externally publishedYes

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Chromosomes, Human, Pair 14
Enterovirus
Myocarditis
Cardiomyopathies
Autoimmune Diseases
Congenic Mice
Inbred Strains Mice
Genes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Susceptibility to coxsackievirus B3-induced chronic myocarditis maps near the murine Tcrα and Myhcα loci on chromosome 14. / Traystman, Monica D.; Chow, Lawrence H.; McManus, Bruce M.; Herskowitz, Ahvie; Nesbitt, Muriel N.; Beisel, Kirk.

In: American Journal of Pathology, Vol. 138, No. 3, 03.1991, p. 721-726.

Research output: Contribution to journalArticle

Traystman, Monica D. ; Chow, Lawrence H. ; McManus, Bruce M. ; Herskowitz, Ahvie ; Nesbitt, Muriel N. ; Beisel, Kirk. / Susceptibility to coxsackievirus B3-induced chronic myocarditis maps near the murine Tcrα and Myhcα loci on chromosome 14. In: American Journal of Pathology. 1991 ; Vol. 138, No. 3. pp. 721-726.
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