Abstract
This study was undertaken to determine the genetic control of host susceptibility to coxsackievirus B3 (CVB3)-induced chronic myocarditis in a mouse model. An autosomal recessive autoimmune myocardial disease (amd) gene (possibly more than one gene), which determined susceptibility to CVB3-induced chronic myocarditis in the A/J and DBA/2J inbred mouse strains, was mapped to a segment of chromosome 14. Data from both the AXB/BXA recombinant inbred (RI) strains and the B10.D2(57N) H-8b congenic mice supported this linkage relationship. Analysis of the AXB/BXA RI strain distribution patterns suggested that amd maps distal to the Np-2, Tcrα, and Myhcα loci.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 721-726 |
| Number of pages | 6 |
| Journal | American Journal of Pathology |
| Volume | 138 |
| Issue number | 3 |
| State | Published - Jan 1 1991 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
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Traystman, M. D., Chow, L. H., McManus, B. M., Herskowitz, A., Nesbitt, M. N., & Beisel, K. W. (1991). Susceptibility to coxsackievirus B3-induced chronic myocarditis maps near the murine Tcrα and Myhcα loci on chromosome 14. American Journal of Pathology, 138(3), 721-726.