Susceptibility to coxsackievirus B3-induced chronic myocarditis maps near the murine Tcrα and Myhcα loci on chromosome 14

Monica D. Traystman, Lawrence H. Chow, Bruce M. McManus, Ahvie Herskowitz, Muriel N. Nesbitt, Kirk Beisel

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Abstract

This study was undertaken to determine the genetic control of host susceptibility to coxsackievirus B3 (CVB3)-induced chronic myocarditis in a mouse model. An autosomal recessive autoimmune myocardial disease (amd) gene (possibly more than one gene), which determined susceptibility to CVB3-induced chronic myocarditis in the A/J and DBA/2J inbred mouse strains, was mapped to a segment of chromosome 14. Data from both the AXB/BXA recombinant inbred (RI) strains and the B10.D2(57N) H-8b congenic mice supported this linkage relationship. Analysis of the AXB/BXA RI strain distribution patterns suggested that amd maps distal to the Np-2, Tcrα, and Myhcα loci.

Original languageEnglish
Pages (from-to)721-726
Number of pages6
JournalAmerican Journal of Pathology
Volume138
Issue number3
StatePublished - Mar 1991
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Traystman, M. D., Chow, L. H., McManus, B. M., Herskowitz, A., Nesbitt, M. N., & Beisel, K. (1991). Susceptibility to coxsackievirus B3-induced chronic myocarditis maps near the murine Tcrα and Myhcα loci on chromosome 14. American Journal of Pathology, 138(3), 721-726.