Susceptibility to coxsackievirus B3-induced chronic myocarditis maps near the murine Tcrα and Myhcα loci on chromosome 14

M. D. Traystman, L. H. Chow, B. M. McManus, A. Herskowitz, M. N. Nesbitt, K. W. Beisel

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13 Scopus citations

Abstract

This study was undertaken to determine the genetic control of host susceptibility to coxsackievirus B3 (CVB3)-induced chronic myocarditis in a mouse model. An autosomal recessive autoimmune myocardial disease (amd) gene (possibly more than one gene), which determined susceptibility to CVB3-induced chronic myocarditis in the A/J and DBA/2J inbred mouse strains, was mapped to a segment of chromosome 14. Data from both the AXB/BXA recombinant inbred (RI) strains and the B10.D2(57N) H-8b congenic mice supported this linkage relationship. Analysis of the AXB/BXA RI strain distribution patterns suggested that amd maps distal to the Np-2, Tcrα, and Myhcα loci.

Original languageEnglish (US)
Pages (from-to)721-726
Number of pages6
JournalAmerican Journal of Pathology
Volume138
Issue number3
StatePublished - Jan 1 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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    Traystman, M. D., Chow, L. H., McManus, B. M., Herskowitz, A., Nesbitt, M. N., & Beisel, K. W. (1991). Susceptibility to coxsackievirus B3-induced chronic myocarditis maps near the murine Tcrα and Myhcα loci on chromosome 14. American Journal of Pathology, 138(3), 721-726.