Abstract
This study was undertaken to determine the genetic control of host susceptibility to coxsackievirus B3 (CVB3)-induced chronic myocarditis in a mouse model. An autosomal recessive autoimmune myocardial disease (amd) gene (possibly more than one gene), which determined susceptibility to CVB3-induced chronic myocarditis in the A/J and DBA/2J inbred mouse strains, was mapped to a segment of chromosome 14. Data from both the AXB/BXA recombinant inbred (RI) strains and the B10.D2(57N) H-8b congenic mice supported this linkage relationship. Analysis of the AXB/BXA RI strain distribution patterns suggested that amd maps distal to the Np-2, Tcrα, and Myhcα loci.
| Original language | English |
|---|---|
| Pages (from-to) | 721-726 |
| Number of pages | 6 |
| Journal | American Journal of Pathology |
| Volume | 138 |
| Issue number | 3 |
| State | Published - Mar 1991 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
Cite this
Susceptibility to coxsackievirus B3-induced chronic myocarditis maps near the murine Tcrα and Myhcα loci on chromosome 14. / Traystman, Monica D.; Chow, Lawrence H.; McManus, Bruce M.; Herskowitz, Ahvie; Nesbitt, Muriel N.; Beisel, Kirk.
In: American Journal of Pathology, Vol. 138, No. 3, 03.1991, p. 721-726.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Susceptibility to coxsackievirus B3-induced chronic myocarditis maps near the murine Tcrα and Myhcα loci on chromosome 14
AU - Traystman, Monica D.
AU - Chow, Lawrence H.
AU - McManus, Bruce M.
AU - Herskowitz, Ahvie
AU - Nesbitt, Muriel N.
AU - Beisel, Kirk
PY - 1991/3
Y1 - 1991/3
N2 - This study was undertaken to determine the genetic control of host susceptibility to coxsackievirus B3 (CVB3)-induced chronic myocarditis in a mouse model. An autosomal recessive autoimmune myocardial disease (amd) gene (possibly more than one gene), which determined susceptibility to CVB3-induced chronic myocarditis in the A/J and DBA/2J inbred mouse strains, was mapped to a segment of chromosome 14. Data from both the AXB/BXA recombinant inbred (RI) strains and the B10.D2(57N) H-8b congenic mice supported this linkage relationship. Analysis of the AXB/BXA RI strain distribution patterns suggested that amd maps distal to the Np-2, Tcrα, and Myhcα loci.
AB - This study was undertaken to determine the genetic control of host susceptibility to coxsackievirus B3 (CVB3)-induced chronic myocarditis in a mouse model. An autosomal recessive autoimmune myocardial disease (amd) gene (possibly more than one gene), which determined susceptibility to CVB3-induced chronic myocarditis in the A/J and DBA/2J inbred mouse strains, was mapped to a segment of chromosome 14. Data from both the AXB/BXA recombinant inbred (RI) strains and the B10.D2(57N) H-8b congenic mice supported this linkage relationship. Analysis of the AXB/BXA RI strain distribution patterns suggested that amd maps distal to the Np-2, Tcrα, and Myhcα loci.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026029349&partnerID=8YFLogxK
M3 - Article
C2 - 1848043
AN - SCOPUS:0026029349
VL - 138
SP - 721
EP - 726
JO - American Journal of Pathology
JF - American Journal of Pathology
SN - 0002-9440
IS - 3
ER -