Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer (ICG-HNPC) criteria and results of genetic diagnosis

Jae Gahb Park, Hans F.A. Vasen, Kyu Joo Park, Paivi Peltomaki, Maurizio Ponz De Leon, Miguel A. Rodriguez-Bigas, Jan Lubinski, Nicholas E. Beck, Marie Luise Bisgaard, Michiko Miyaki, Juul Th Wijnen, Shozo Baba, Henry T. Lynch

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

PURPOSE: The aim of this study was to determine the frequency of mutations in the mismatch repair genes in families suspected of having hereditary nonpolyposis colorectal cancer. METHODS: We devised two criteria for families suspected of having hereditary nonpolyposis colorectal cancer (Criteria I and II). Criteria I consist of at least two first-degree relatives affected with colorectal cancer with at least one of the following: development of multiple colorectal tumors including adenomatous polyp, at least one colorectal cancer case diagnosed before the age of 50, and occurrence of a hereditary nonpolyposis colorectal cancer extracolonic cancer (endometrium, urinary tract, small intestine, stomach, hepatobiliary system, or ovary) in family members. Criteria II consist of one colorectal cancer patient with at least one of the following: early age of onset (

Original languageEnglish (US)
Pages (from-to)710-716
Number of pages7
JournalDiseases of the Colon and Rectum
Volume42
Issue number6
DOIs
StatePublished - Jun 1 1999

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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