TY - JOUR
T1 - Suspected hereditary nonpolyposis colorectal cancer
T2 - International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer (ICG-HNPC) criteria and results of genetic diagnosis
AU - Park, Jae Gahb
AU - Vasen, Hans F A
AU - Park, Kyu Joo
AU - Peltomaki, Paivi
AU - Ponz De Leon, Maurizio
AU - Rodriguez-Bigas, Miguel A.
AU - Lubinski, Jan
AU - Beck, Nicholas E.
AU - Bisgaard, Marie Luise
AU - Miyaki, Michiko
AU - Wijnen, Juul Th
AU - Baba, Shozo
AU - Lynch, Henry T.
PY - 1999/6
Y1 - 1999/6
N2 - PURPOSE: The aim of this study was to determine the frequency of mutations in the mismatch repair genes in families suspected of having hereditary nonpolyposis colorectal cancer. METHODS: We devised two criteria for families suspected of having hereditary nonpolyposis colorectal cancer (Criteria I and II). Criteria I consist of at least two first-degree relatives affected with colorectal cancer with at least one of the following: development of multiple colorectal tumors including adenomatous polyp, at least one colorectal cancer case diagnosed before the age of 50, and occurrence of a hereditary nonpolyposis colorectal cancer extracolonic cancer (endometrium, urinary tract, small intestine, stomach, hepatobiliary system, or ovary) in family members. Criteria II consist of one colorectal cancer patient with at least one of the following: early age of onset (
AB - PURPOSE: The aim of this study was to determine the frequency of mutations in the mismatch repair genes in families suspected of having hereditary nonpolyposis colorectal cancer. METHODS: We devised two criteria for families suspected of having hereditary nonpolyposis colorectal cancer (Criteria I and II). Criteria I consist of at least two first-degree relatives affected with colorectal cancer with at least one of the following: development of multiple colorectal tumors including adenomatous polyp, at least one colorectal cancer case diagnosed before the age of 50, and occurrence of a hereditary nonpolyposis colorectal cancer extracolonic cancer (endometrium, urinary tract, small intestine, stomach, hepatobiliary system, or ovary) in family members. Criteria II consist of one colorectal cancer patient with at least one of the following: early age of onset (
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U2 - 10.1007/BF02236922
DO - 10.1007/BF02236922
M3 - Article
C2 - 10378593
AN - SCOPUS:0033039409
VL - 42
SP - 710
EP - 716
JO - Diseases of the Colon and Rectum
JF - Diseases of the Colon and Rectum
SN - 0012-3706
IS - 6
ER -