Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer (ICG-HNPC) criteria and results of genetic diagnosis

Jae Gahb Park; Hans F.A. Vasen; Kyu Joo Park; Paivi Peltomaki; Maurizio Ponz De Leon; Miguel A. Rodriguez-Bigas; Jan Lubinski; Nicholas E. Beck; Marie Luise Bisgaard; Michiko Miyaki; Juul Th Wijnen; Shozo Baba; Henry T. Lynch

doi:10.1007/BF02236922

Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer (ICG-HNPC) criteria and results of genetic diagnosis

Jae Gahb Park, Hans F.A. Vasen, Kyu Joo Park, Paivi Peltomaki, Maurizio Ponz De Leon, Miguel A. Rodriguez-Bigas, Jan Lubinski, Nicholas E. Beck, Marie Luise Bisgaard, Michiko Miyaki, Juul Th Wijnen, Shozo Baba, Henry T. Lynch

Department of Preventive Medicine

Research output: Contribution to journal › Article

91 Scopus citations

Abstract

PURPOSE: The aim of this study was to determine the frequency of mutations in the mismatch repair genes in families suspected of having hereditary nonpolyposis colorectal cancer. METHODS: We devised two criteria for families suspected of having hereditary nonpolyposis colorectal cancer (Criteria I and II). Criteria I consist of at least two first-degree relatives affected with colorectal cancer with at least one of the following: development of multiple colorectal tumors including adenomatous polyp, at least one colorectal cancer case diagnosed before the age of 50, and occurrence of a hereditary nonpolyposis colorectal cancer extracolonic cancer (endometrium, urinary tract, small intestine, stomach, hepatobiliary system, or ovary) in family members. Criteria II consist of one colorectal cancer patient with at least one of the following: early age of onset (

Original language	English (US)
Pages (from-to)	710-716
Number of pages	7
Journal	Diseases of the Colon and Rectum
Volume	42
Issue number	6
DOIs	https://doi.org/10.1007/BF02236922
State	Published - Jun 1 1999

All Science Journal Classification (ASJC) codes

Gastroenterology

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10.1007/BF02236922

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Park, J. G., Vasen, H. F. A., Park, K. J., Peltomaki, P., Ponz De Leon, M., Rodriguez-Bigas, M. A., Lubinski, J., Beck, N. E., Bisgaard, M. L., Miyaki, M., Wijnen, J. T., Baba, S., & Lynch, H. T. (1999). Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer (ICG-HNPC) criteria and results of genetic diagnosis. Diseases of the Colon and Rectum, 42(6), 710-716. https://doi.org/10.1007/BF02236922

Suspected hereditary nonpolyposis colorectal cancer : International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer (ICG-HNPC) criteria and results of genetic diagnosis. / Park, Jae Gahb; Vasen, Hans F.A.; Park, Kyu Joo; Peltomaki, Paivi; Ponz De Leon, Maurizio; Rodriguez-Bigas, Miguel A.; Lubinski, Jan; Beck, Nicholas E.; Bisgaard, Marie Luise; Miyaki, Michiko; Wijnen, Juul Th; Baba, Shozo; Lynch, Henry T.

In: Diseases of the Colon and Rectum, Vol. 42, No. 6, 01.06.1999, p. 710-716.

Research output: Contribution to journal › Article

Park, JG, Vasen, HFA, Park, KJ, Peltomaki, P, Ponz De Leon, M, Rodriguez-Bigas, MA, Lubinski, J, Beck, NE, Bisgaard, ML, Miyaki, M, Wijnen, JT, Baba, S & Lynch, HT 1999, 'Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer (ICG-HNPC) criteria and results of genetic diagnosis', Diseases of the Colon and Rectum, vol. 42, no. 6, pp. 710-716. https://doi.org/10.1007/BF02236922

Park, Jae Gahb ; Vasen, Hans F.A. ; Park, Kyu Joo ; Peltomaki, Paivi ; Ponz De Leon, Maurizio ; Rodriguez-Bigas, Miguel A. ; Lubinski, Jan ; Beck, Nicholas E. ; Bisgaard, Marie Luise ; Miyaki, Michiko ; Wijnen, Juul Th ; Baba, Shozo ; Lynch, Henry T. / Suspected hereditary nonpolyposis colorectal cancer : International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer (ICG-HNPC) criteria and results of genetic diagnosis. In: Diseases of the Colon and Rectum. 1999 ; Vol. 42, No. 6. pp. 710-716.

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abstract = "PURPOSE: The aim of this study was to determine the frequency of mutations in the mismatch repair genes in families suspected of having hereditary nonpolyposis colorectal cancer. METHODS: We devised two criteria for families suspected of having hereditary nonpolyposis colorectal cancer (Criteria I and II). Criteria I consist of at least two first-degree relatives affected with colorectal cancer with at least one of the following: development of multiple colorectal tumors including adenomatous polyp, at least one colorectal cancer case diagnosed before the age of 50, and occurrence of a hereditary nonpolyposis colorectal cancer extracolonic cancer (endometrium, urinary tract, small intestine, stomach, hepatobiliary system, or ovary) in family members. Criteria II consist of one colorectal cancer patient with at least one of the following: early age of onset (",

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