Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer

CHEST Guideline and Expert Panel Report

CHEST Expert Cough Panel

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background Cough among patients with lung cancer is a common but often undertreated symptom. We used a 2015 Cochrane systematic review, among other sources of evidence, to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline on this topic. Methods The CHEST methodologic guidelines and the Grading of Recommendations, Assessment, Development, and Evaluation framework were used. The Expert Cough Panel based their recommendations on data from the Cochrane systematic review on the topic, uncontrolled studies, case studies, and the clinical context. Final grading was reached by consensus according to the Delphi method. Results The Cochrane systematic review identified 17 trials of primarily low-quality evidence. Such evidence was related to both nonpharmacologic (cough suppression) and pharmacologic (demulcents, opioids, peripherally acting antitussives, or local anesthetics) treatments, as well as endobronchial brachytherapy. Conclusions Compared with the 2006 CHEST Cough Guideline, the current recommendations and suggestions are more specific and follow a step-up approach to the management of cough among patients with lung cancer, acknowledging the low-quality evidence in the field and the urgent need to develop more effective, evidence-based interventions through high-quality research.

Original languageEnglish (US)
Pages (from-to)861-874
Number of pages14
JournalChest
Volume151
Issue number4
DOIs
StatePublished - Apr 1 2017

Fingerprint

Cough
Lung Neoplasms
Guidelines
Antitussive Agents
Therapeutics
Brachytherapy
Local Anesthetics
Opioid Analgesics
Research

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer : CHEST Guideline and Expert Panel Report. / CHEST Expert Cough Panel.

In: Chest, Vol. 151, No. 4, 01.04.2017, p. 861-874.

Research output: Contribution to journalArticle

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title = "Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer: CHEST Guideline and Expert Panel Report",
abstract = "Background Cough among patients with lung cancer is a common but often undertreated symptom. We used a 2015 Cochrane systematic review, among other sources of evidence, to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline on this topic. Methods The CHEST methodologic guidelines and the Grading of Recommendations, Assessment, Development, and Evaluation framework were used. The Expert Cough Panel based their recommendations on data from the Cochrane systematic review on the topic, uncontrolled studies, case studies, and the clinical context. Final grading was reached by consensus according to the Delphi method. Results The Cochrane systematic review identified 17 trials of primarily low-quality evidence. Such evidence was related to both nonpharmacologic (cough suppression) and pharmacologic (demulcents, opioids, peripherally acting antitussives, or local anesthetics) treatments, as well as endobronchial brachytherapy. Conclusions Compared with the 2006 CHEST Cough Guideline, the current recommendations and suggestions are more specific and follow a step-up approach to the management of cough among patients with lung cancer, acknowledging the low-quality evidence in the field and the urgent need to develop more effective, evidence-based interventions through high-quality research.",
author = "{CHEST Expert Cough Panel} and Alex Molassiotis and Smith, {Jaclyn A.} and Peter Mazzone and Fiona Blackhall and Irwin, {Richard S.} and Adams, {Todd M.} and Altman, {Kenneth W.} and Barker, {Alan F.} and Birring, {Surinder S.} and Fiona Blackhall and Bolser, {Donald C.} and Boulet, {Louis Philippe} and Braman, {Sidney S.} and Christopher Brightling and Priscilla Callahan-Lyon and Canning, {Brendan J.} and Chang, {Anne B.} and Terrie Cowley and Paul Davenport and Satoru Ebihara and {El Solh}, {Ali A.} and Patricio Escalante and Field, {Stephen K.} and Dina Fisher and French, {Cynthia T.} and Peter Gibson and Philip Gold and Cameron Grant and Anthony Harnden and Hill, {Adam T.} and Irwin, {Richard S.} and Kahrilas, {Peter J.} and Keogh, {Karina A.} and Kefang Lai and Lane, {Andrew P.} and Malesker, {Mark A.} and Peter Mazzone and Stuart Mazzone and Alex Molassiotis and Murad, {M. Hassan} and Peter Newcombe and Nguyen, {Huong Q.} and John Oppenheimer and Restrepo, {Marcos I.} and Mark Rosen and Bruce Rubin and Ryu, {Jay H.} and Jaclyn Smith and Tarlo, {Susan M.} and Julie Turmel",
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T1 - Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer

T2 - CHEST Guideline and Expert Panel Report

AU - CHEST Expert Cough Panel

AU - Molassiotis, Alex

AU - Smith, Jaclyn A.

AU - Mazzone, Peter

AU - Blackhall, Fiona

AU - Irwin, Richard S.

AU - Adams, Todd M.

AU - Altman, Kenneth W.

AU - Barker, Alan F.

AU - Birring, Surinder S.

AU - Blackhall, Fiona

AU - Bolser, Donald C.

AU - Boulet, Louis Philippe

AU - Braman, Sidney S.

AU - Brightling, Christopher

AU - Callahan-Lyon, Priscilla

AU - Canning, Brendan J.

AU - Chang, Anne B.

AU - Cowley, Terrie

AU - Davenport, Paul

AU - Ebihara, Satoru

AU - El Solh, Ali A.

AU - Escalante, Patricio

AU - Field, Stephen K.

AU - Fisher, Dina

AU - French, Cynthia T.

AU - Gibson, Peter

AU - Gold, Philip

AU - Grant, Cameron

AU - Harnden, Anthony

AU - Hill, Adam T.

AU - Irwin, Richard S.

AU - Kahrilas, Peter J.

AU - Keogh, Karina A.

AU - Lai, Kefang

AU - Lane, Andrew P.

AU - Malesker, Mark A.

AU - Mazzone, Peter

AU - Mazzone, Stuart

AU - Molassiotis, Alex

AU - Murad, M. Hassan

AU - Newcombe, Peter

AU - Nguyen, Huong Q.

AU - Oppenheimer, John

AU - Restrepo, Marcos I.

AU - Rosen, Mark

AU - Rubin, Bruce

AU - Ryu, Jay H.

AU - Smith, Jaclyn

AU - Tarlo, Susan M.

AU - Turmel, Julie

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background Cough among patients with lung cancer is a common but often undertreated symptom. We used a 2015 Cochrane systematic review, among other sources of evidence, to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline on this topic. Methods The CHEST methodologic guidelines and the Grading of Recommendations, Assessment, Development, and Evaluation framework were used. The Expert Cough Panel based their recommendations on data from the Cochrane systematic review on the topic, uncontrolled studies, case studies, and the clinical context. Final grading was reached by consensus according to the Delphi method. Results The Cochrane systematic review identified 17 trials of primarily low-quality evidence. Such evidence was related to both nonpharmacologic (cough suppression) and pharmacologic (demulcents, opioids, peripherally acting antitussives, or local anesthetics) treatments, as well as endobronchial brachytherapy. Conclusions Compared with the 2006 CHEST Cough Guideline, the current recommendations and suggestions are more specific and follow a step-up approach to the management of cough among patients with lung cancer, acknowledging the low-quality evidence in the field and the urgent need to develop more effective, evidence-based interventions through high-quality research.

AB - Background Cough among patients with lung cancer is a common but often undertreated symptom. We used a 2015 Cochrane systematic review, among other sources of evidence, to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline on this topic. Methods The CHEST methodologic guidelines and the Grading of Recommendations, Assessment, Development, and Evaluation framework were used. The Expert Cough Panel based their recommendations on data from the Cochrane systematic review on the topic, uncontrolled studies, case studies, and the clinical context. Final grading was reached by consensus according to the Delphi method. Results The Cochrane systematic review identified 17 trials of primarily low-quality evidence. Such evidence was related to both nonpharmacologic (cough suppression) and pharmacologic (demulcents, opioids, peripherally acting antitussives, or local anesthetics) treatments, as well as endobronchial brachytherapy. Conclusions Compared with the 2006 CHEST Cough Guideline, the current recommendations and suggestions are more specific and follow a step-up approach to the management of cough among patients with lung cancer, acknowledging the low-quality evidence in the field and the urgent need to develop more effective, evidence-based interventions through high-quality research.

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