Abstract
A polyenoic fatty-acid isomerase (PFI) from a red marine alga was used to convert anandamide (5Z,8Z,11Z,14Z-eicosatetraenoyl-N-ethanolamide to the 5Z,7E,9E,14Z-eicosatetraenoyl-N-ethanolamide isomer. This novel eicosanoid, termed conjugated triene anandamide (CTA), was assessed for its ability to bind to the cannabinoid receptor in rat brain membrane preparations. CTA is a high affinity cannabimimetic substance whose novel structure provides new insight into structure-activity relationships of cannabinoid receptor ligands. These experiments illustrate the utility of enzymes isolated from marine organisms in the development of pharmacological probes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 88-92 |
| Number of pages | 5 |
| Journal | Experientia |
| Volume | 52 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1996 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
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Wise, M. L., Soderstrom, K., Murray, T. F., & Gerwick, W. H. (1996). Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid. Experientia, 52(1), 88-92. https://doi.org/10.1007/BF01922423