Synthesis and characterization of hydroxyapatite-ciprofloxacin delivery systems by precipitation and spray drying technique

Hai H. Pham, Ping Luo, François Génin, Alekha K. Dash

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

This investigation synthesized and characterized hydroxyapatite (HAP) microspheres, agglomerated microspheres, and implants containing ciprofloxacin. This delivery system is to be used as an implantable drug delivery system for the treatment of bone infections. The HAP microspheres were made by chemical precipitation followed by a spray-drying technique. Agglomerated microspheres were prepared by a wet granulation process using a granulator. Implants were prepared by direct compression of the granules on a Carver press. Ciprofloxacin was analyzed by high-performance liquid chromatography. Characterization of the HAP microspheres include particle size, size distribution, physical state of the drug in the microsphere, and microstructure of the drug delivery system before and after in vitro release. The particle size, porosity, and morphology of the microspheres were dependent on viscosity and concentration of the slurry as well as the atomization pressure used during spray drying. Even at the highest drug load (2% wt/wt), the drug was present in a noncrystalline state. The drug release from the agglomerated microspheres was quick and almost complete within 1 hour. However, compressing the same amount of agglomerated microspheres into an implant greatly reduced the rate of ciprofloxacin release. Only 12% (wt/wt) of the drug was released from the implant within 1 hour. The in vitro release of ciprofloxacin from these implants follows a diffusion-controlled mechanism. This method provides a unique way of producing various shapes and drug loads of HAP microspheres that can be easily manufactured on a commercial scale.

Original languageEnglish
JournalAAPS PharmSciTech
Volume3
Issue number1
StatePublished - Jan 28 2002

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hydroxyapatite
spray drying
ciprofloxacin
Durapatite
Ciprofloxacin
Microspheres
drugs
synthesis
drug delivery systems
particle size
chemical precipitation
methodology
Pharmaceutical Preparations
atomization
Particle Size
Implantable Infusion Pumps
Chemical Precipitation
microstructure
porosity
granules

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Synthesis and characterization of hydroxyapatite-ciprofloxacin delivery systems by precipitation and spray drying technique. / Pham, Hai H.; Luo, Ping; Génin, François; Dash, Alekha K.

In: AAPS PharmSciTech, Vol. 3, No. 1, 28.01.2002.

Research output: Contribution to journalArticle

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