Synthesis and opioid activity of [D-Pro¹⁰]Dynorphin A-(1-11) analogues with N-terminal alkyl substitution

Medicine & Life Sciences

• Dynorphins 100%
• Tyrosine 67%
• Opioid Analgesics 64%
• Ileum 49%
• Peptides 46%
• phenylbenzoquinone 43%
• Guinea Pigs 42%
• Solid-Phase Synthesis Techniques 39%
• Peptide Receptors 30%
• Opioid Peptides 30%
• Structure-Activity Relationship 28%
• Opioid Receptors 27%
• Esters 24%
• Amino Acids 17%
• (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 3%

Chemical Compounds

• Agonist 70%
• Antinociceptive 50%
• Substitution Reaction 46%
• Tyrosine Derivative 38%
• Alkyl Group 35%
• Antagonist 34%
• Peptide 21%
• Opiate Peptide 16%
• Phosphonium 13%
• Tyrosine 11%
• Structure-Activity Relationship 10%
• Tris 10%
• Halide 9%
• Ester 7%
• Acid 4%