Synthesis of a disulfide cross-linked DNA triple helix

Jay T. Goodwin, Scott E. Osborne, Patrick Swanson, Gary D. Glick

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

An intramolecular DNA triple helix incorporating a disulfide cross-link has been synthesized. Potassium permanganate footprinting and UV melting analysis demonstrate that the cross-link increases the conformational stability of this novel triplex at physiological pH and [Mg2+] relative to the unmodified sequence.

Original languageEnglish
Pages (from-to)4527-4530
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number26
DOIs
StatePublished - Jun 27 1994
Externally publishedYes

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Potassium Permanganate
Disulfides
Freezing
Melting
DNA

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of a disulfide cross-linked DNA triple helix. / Goodwin, Jay T.; Osborne, Scott E.; Swanson, Patrick; Glick, Gary D.

In: Tetrahedron Letters, Vol. 35, No. 26, 27.06.1994, p. 4527-4530.

Research output: Contribution to journal › Article

Goodwin, JT, Osborne, SE, Swanson, P & Glick, GD 1994, 'Synthesis of a disulfide cross-linked DNA triple helix', Tetrahedron Letters, vol. 35, no. 26, pp. 4527-4530. https://doi.org/10.1016/S0040-4039(00)60718-9
Goodwin JT, Osborne SE, Swanson P, Glick GD. Synthesis of a disulfide cross-linked DNA triple helix. Tetrahedron Letters. 1994 Jun 27;35(26):4527-4530. https://doi.org/10.1016/S0040-4039(00)60718-9
Goodwin, Jay T. ; Osborne, Scott E. ; Swanson, Patrick ; Glick, Gary D. / Synthesis of a disulfide cross-linked DNA triple helix. In: Tetrahedron Letters. 1994 ; Vol. 35, No. 26. pp. 4527-4530.
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