Synthesis of a disulfide cross-linked DNA triple helix

Jay T. Goodwin, Scott E. Osborne, Patrick C. Swanson, Gary D. Glick

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


An intramolecular DNA triple helix incorporating a disulfide cross-link has been synthesized. Potassium permanganate footprinting and UV melting analysis demonstrate that the cross-link increases the conformational stability of this novel triplex at physiological pH and [Mg2+] relative to the unmodified sequence.

Original languageEnglish (US)
Pages (from-to)4527-4530
Number of pages4
JournalTetrahedron Letters
Issue number26
StatePublished - Jun 27 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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