Abstract
An intramolecular DNA triple helix incorporating a disulfide cross-link has been synthesized. Potassium permanganate footprinting and UV melting analysis demonstrate that the cross-link increases the conformational stability of this novel triplex at physiological pH and [Mg2+] relative to the unmodified sequence.
Original language | English (US) |
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Pages (from-to) | 4527-4530 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 35 |
Issue number | 26 |
DOIs | |
State | Published - Jun 27 1994 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry