Synthesis of a disulfide cross-linked DNA triple helix

Jay T. Goodwin; Scott E. Osborne; Patrick C. Swanson; Gary D. Glick

doi:10.1016/S0040-4039(00)60718-9

Synthesis of a disulfide cross-linked DNA triple helix

Jay T. Goodwin, Scott E. Osborne, Patrick C. Swanson, Gary D. Glick

Department of Medical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

An intramolecular DNA triple helix incorporating a disulfide cross-link has been synthesized. Potassium permanganate footprinting and UV melting analysis demonstrate that the cross-link increases the conformational stability of this novel triplex at physiological pH and [Mg²⁺] relative to the unmodified sequence.

Original language	English (US)
Pages (from-to)	4527-4530
Number of pages	4
Journal	Tetrahedron Letters
Volume	35
Issue number	26
DOIs	https://doi.org/10.1016/S0040-4039(00)60718-9
State	Published - Jun 27 1994

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Synthesis of a disulfide cross-linked DNA triple helix",

abstract = "An intramolecular DNA triple helix incorporating a disulfide cross-link has been synthesized. Potassium permanganate footprinting and UV melting analysis demonstrate that the cross-link increases the conformational stability of this novel triplex at physiological pH and [Mg2+] relative to the unmodified sequence.",

author = "Goodwin, {Jay T.} and Osborne, {Scott E.} and Swanson, {Patrick C.} and Glick, {Gary D.}",

year = "1994",

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T1 - Synthesis of a disulfide cross-linked DNA triple helix

AU - Goodwin, Jay T.

AU - Osborne, Scott E.

AU - Swanson, Patrick C.

AU - Glick, Gary D.

PY - 1994/6/27

Y1 - 1994/6/27

N2 - An intramolecular DNA triple helix incorporating a disulfide cross-link has been synthesized. Potassium permanganate footprinting and UV melting analysis demonstrate that the cross-link increases the conformational stability of this novel triplex at physiological pH and [Mg2+] relative to the unmodified sequence.

AB - An intramolecular DNA triple helix incorporating a disulfide cross-link has been synthesized. Potassium permanganate footprinting and UV melting analysis demonstrate that the cross-link increases the conformational stability of this novel triplex at physiological pH and [Mg2+] relative to the unmodified sequence.

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U2 - 10.1016/S0040-4039(00)60718-9

DO - 10.1016/S0040-4039(00)60718-9

M3 - Article

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VL - 35

SP - 4527

EP - 4530

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

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