TY - JOUR
T1 - Synthetic, structural, and conformational studies of methylated ring-expanded nucleosides containing the imidazo[4,5-e] [1, 4]diazepine ring system
AU - Hosmane, Ramachandra S.
AU - Bhan, Anila
AU - Hulce, Martin
AU - Zhang, Hongming
AU - Hosmane, Narayan S.
PY - 1991/6/1
Y1 - 1991/6/1
N2 - Syntheses of 4- and 7-methyl 4, 5, 7, 8-tetrahydro-6H-3-(β-D-ribofuranosyl)imidazo[4, 5-e] [1, 4]diazepine-5, 8-dione, 3 and 4, respectively, are reported. Single-crystal X-ray diffraction analysis of the aglycon of 3 aided in confirming the site of methylation in 3, and that of 4 in elucidating the solid state conformation of 4. Solution conformations of 3 and 4, along with their parent nucleoside 1 and the latter's 1-glycosyl regioisomer 2, were investigated by NOE and CD measurements.
AB - Syntheses of 4- and 7-methyl 4, 5, 7, 8-tetrahydro-6H-3-(β-D-ribofuranosyl)imidazo[4, 5-e] [1, 4]diazepine-5, 8-dione, 3 and 4, respectively, are reported. Single-crystal X-ray diffraction analysis of the aglycon of 3 aided in confirming the site of methylation in 3, and that of 4 in elucidating the solid state conformation of 4. Solution conformations of 3 and 4, along with their parent nucleoside 1 and the latter's 1-glycosyl regioisomer 2, were investigated by NOE and CD measurements.
UR - http://www.scopus.com/inward/record.url?scp=0025812027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025812027&partnerID=8YFLogxK
U2 - 10.1080/07328319108046664
DO - 10.1080/07328319108046664
M3 - Article
AN - SCOPUS:0025812027
VL - 10
SP - 819
EP - 836
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
SN - 1525-7770
IS - 4
ER -