Abstract
Syntheses of 4- and 7-methyl 4, 5, 7, 8-tetrahydro-6H-3-(β-D-ribofuranosyl)imidazo[4, 5-e] [1, 4]diazepine-5, 8-dione, 3 and 4, respectively, are reported. Single-crystal X-ray diffraction analysis of the aglycon of 3 aided in confirming the site of methylation in 3, and that of 4 in elucidating the solid state conformation of 4. Solution conformations of 3 and 4, along with their parent nucleoside 1 and the latter's 1-glycosyl regioisomer 2, were investigated by NOE and CD measurements.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 819-836 |
| Number of pages | 18 |
| Journal | Nucleosides and Nucleotides |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jun 1 1991 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Genetics
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Hosmane, R. S., Bhan, A., Hulce, M., Zhang, H., & Hosmane, N. S. (1991). Synthetic, structural, and conformational studies of methylated ring-expanded nucleosides containing the imidazo[4,5-e] [1, 4]diazepine ring system. Nucleosides and Nucleotides, 10(4), 819-836. https://doi.org/10.1080/07328319108046664