Abstract
Syntheses of 4- and 7-methyl 4, 5, 7, 8-tetrahydro-6H-3-(β-D-ribofuranosyl)imidazo[4, 5-e] [1, 4]diazepine-5, 8-dione, 3 and 4, respectively, are reported. Single-crystal X-ray diffraction analysis of the aglycon of 3 aided in confirming the site of methylation in 3, and that of 4 in elucidating the solid state conformation of 4. Solution conformations of 3 and 4, along with their parent nucleoside 1 and the latter's 1-glycosyl regioisomer 2, were investigated by NOE and CD measurements.
| Original language | English |
|---|---|
| Pages (from-to) | 819-836 |
| Number of pages | 18 |
| Journal | Nucleosides and Nucleotides |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jun 1 1991 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Genetics
Cite this
Synthetic, structural, and conformational studies of methylated ring-expanded nucleosides containing the imidazo[4,5-e] [1, 4]diazepine ring system. / Hosmane, Ramachandra S.; Bhan, Anila; Hulce, Martin; Zhang, Hongming; Hosmane, Narayan S.
In: Nucleosides and Nucleotides, Vol. 10, No. 4, 01.06.1991, p. 819-836.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Synthetic, structural, and conformational studies of methylated ring-expanded nucleosides containing the imidazo[4,5-e] [1, 4]diazepine ring system
AU - Hosmane, Ramachandra S.
AU - Bhan, Anila
AU - Hulce, Martin
AU - Zhang, Hongming
AU - Hosmane, Narayan S.
PY - 1991/6/1
Y1 - 1991/6/1
N2 - Syntheses of 4- and 7-methyl 4, 5, 7, 8-tetrahydro-6H-3-(β-D-ribofuranosyl)imidazo[4, 5-e] [1, 4]diazepine-5, 8-dione, 3 and 4, respectively, are reported. Single-crystal X-ray diffraction analysis of the aglycon of 3 aided in confirming the site of methylation in 3, and that of 4 in elucidating the solid state conformation of 4. Solution conformations of 3 and 4, along with their parent nucleoside 1 and the latter's 1-glycosyl regioisomer 2, were investigated by NOE and CD measurements.
AB - Syntheses of 4- and 7-methyl 4, 5, 7, 8-tetrahydro-6H-3-(β-D-ribofuranosyl)imidazo[4, 5-e] [1, 4]diazepine-5, 8-dione, 3 and 4, respectively, are reported. Single-crystal X-ray diffraction analysis of the aglycon of 3 aided in confirming the site of methylation in 3, and that of 4 in elucidating the solid state conformation of 4. Solution conformations of 3 and 4, along with their parent nucleoside 1 and the latter's 1-glycosyl regioisomer 2, were investigated by NOE and CD measurements.
UR - http://www.scopus.com/inward/record.url?scp=0025812027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025812027&partnerID=8YFLogxK
U2 - 10.1080/07328319108046664
DO - 10.1080/07328319108046664
M3 - Article
AN - SCOPUS:0025812027
VL - 10
SP - 819
EP - 836
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
SN - 1525-7770
IS - 4
ER -