TY - JOUR
T1 - Synthetic, structural, and conformational studies of methylated ring-expanded nucleosides containing the imidazo[4,5-e] [1, 4]diazepine ring system
AU - Hosmane, Ramachandra S.
AU - Bhan, Anila
AU - Hulce, Martin
AU - Zhang, Hongming
AU - Hosmane, Narayan S.
N1 - Funding Information:
Acknowledgments. This investigation was supported by the National Institutes of Health (R.S.H. # CA 361541, the American Cancer Society Institutional Research Grant (A.B. # IN-l47H), MD Cancer PrograqAJniv. of Maryland, the American Cancer Society-Maryland Div., Inc. (M.H.), and the National Science Foundation (N.S.H. # CHE-88-00328).
PY - 1991/6/1
Y1 - 1991/6/1
N2 - Syntheses of 4- and 7-methyl 4, 5, 7, 8-tetrahydro-6H-3-(β-D-ribofuranosyl)imidazo[4, 5-e] [1, 4]diazepine-5, 8-dione, 3 and 4, respectively, are reported. Single-crystal X-ray diffraction analysis of the aglycon of 3 aided in confirming the site of methylation in 3, and that of 4 in elucidating the solid state conformation of 4. Solution conformations of 3 and 4, along with their parent nucleoside 1 and the latter's 1-glycosyl regioisomer 2, were investigated by NOE and CD measurements.
AB - Syntheses of 4- and 7-methyl 4, 5, 7, 8-tetrahydro-6H-3-(β-D-ribofuranosyl)imidazo[4, 5-e] [1, 4]diazepine-5, 8-dione, 3 and 4, respectively, are reported. Single-crystal X-ray diffraction analysis of the aglycon of 3 aided in confirming the site of methylation in 3, and that of 4 in elucidating the solid state conformation of 4. Solution conformations of 3 and 4, along with their parent nucleoside 1 and the latter's 1-glycosyl regioisomer 2, were investigated by NOE and CD measurements.
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U2 - 10.1080/07328319108046664
DO - 10.1080/07328319108046664
M3 - Article
AN - SCOPUS:0025812027
VL - 10
SP - 819
EP - 836
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
SN - 1525-7770
IS - 4
ER -